Chia (Salvia hispanica L.) flour promotes beneficial effects on adipose tissue but not on glycaemic profile of diet-induced obesity in mice

Author(s)

Carnier, June ^[1] ; Silva, Fernanda Pinheiro ^[1] ; de Miranda, Danielle Araujo ^[1] ; Santamarina, Aline Boveto ^[2] ; Mennitti, Lais Vales ^[3] ; Moreira, Renata Guimaraes ^[4] ; Oller do Nascimento, Claudia Maria ^[1] ; Ribeiro, Eliane Beraldi ^[1] ; Oyama, Lila Missae ^[1]

Affiliation

^[1] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Interdisciplinaridade Ciencias Saude, Santos, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, Inst Saude & Soc, Santos, SP - Brazil

^[4] Univ Sao Paulo, Dept Fisiol, Inst Biociencias, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY; v. 119, n. 10 OCT 2017.
• Web of Science Citations: 1

Abstract

This study evaluated effects of integral chia flour (Salvia hispanica L.) associated with high-fat diet on glucose metabolism, fatty acid profile, and inflammatory mediators in epididymal adipose and liver tissue using experimental obesity models induced by high-calorie and -fat diets. Forty-eight mice were divided into four experimental groups: control diet (C); control diet+chia flour (CCh); high-fat and -calorie diet (H), and high-fat and -calorie diet+chia flour (HCh). Tissue cytokines, fatty acid profile, and glycaemic profile were measured. In oral glucose tolerance testing, HCh presented higher glycaemia than H at 15, 30, and 120min. In epididymal adipose tissue, CCh showed higher accumulation of alpha-linolenic fatty acid (-LNA) than C, while HCh showed higher accumulation of -LNA and lower concentrations of C20:4n6 fatty acid than H. In liver tissue, CCh presented higher accumulation of -LNA and lower concentrations of C20:4n6 fatty acid than C. We believe that 12g of chia flour per kg of food for 10wk is essential for prevention and treatment of obesity; however, it may be necessary to adjust chia amounts and treatment times to improve glycaemic profiles. This study provides pioneering results on the effects of chia in mice. Practical applications: With the hope of losing weight and becoming healthier, many people adopt radical diets that can be harmful to their health. Accordingly, dietary guidelines must be carefully planned by qualified health professionals, especially considering the comorbidities of diabetes and cardiovascular disease that accompany obesity. In addition, the adequate treatment of obesity increases the chances of the patients maintaining their diet and lifestyle changes, thus, allowing for greater control of their obesity. Consequently, knowledge of the appropriate dosages and effects of chia is important for the development of new tools for composing dietary guidelines for healthy individuals, especially for the treatment of obese patients. Effects of chia flour (Salvia hispanica L.) on liver tissue fatty acid (A) and epididymal adipose tissue fatty acid (B) of all groups after treatment. Data are expressed as mean +/- S.E. {*}, statistical difference of C group; \#, statistical difference of CCh group; , statistical difference of H group (p<0.05). (AU)

• FAPESP's process: 13/12410-9 - Effect of intake of chia (Salvia hispanica L.) in the expression of adipokines and metabolic regulators in adipose tissue, skeletal muscle and liver of mice treated with hyperlipidic and hypercaloric diet
• Grantee: June Carnier
• Support Opportunities: Scholarships in Brazil - Post-Doctorate