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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation

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Author(s):
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Saunders, B. [1] ; de Oliveira, L. F. [1] ; da Silva, R. P. [1] ; de Salles Painelli, V. [1] ; Goncalves, L. S. [1] ; Yamaguchi, G. [1] ; Mutti, T. [1] ; Maciel, E. [2] ; Roschel, H. [1, 2] ; Artioli, G. G. [1, 2] ; Gualano, B. [1, 2]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Rheumatol Div, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 27, n. 11, p. 1240-1247, NOV 2017.
Web of Science Citations: 18
Abstract

We investigated the effects of supplement identification on exercise performance with caffeine supplementation. Forty-two trained cyclists (age 37 +/- 8years, body mass {[}BM] 74.3 +/- 8.4kg, height 1.76 +/- 0.06m, maximum oxygen uptake 50.0 +/- 6.8mL/kg/min) performed a similar to 30min cycling time-trial 1h following either 6mg/kgBM caffeine (CAF) or placebo (PLA) supplementation and one control (CON) session without supplementation. Participants identified which supplement they believed they had ingested (caffeine, placebo, don't know) pre- and post-exercise. Subsequently, participants were allocated to subgroups for analysis according to their identifications. Overall and subgroup analyses were performed using mixed-model and magnitude-based inference analyses. Caffeine improved performance vs PLA and CON (P0.001). Correct pre- and post-exercise identification of caffeine in CAF improved exercise performance (+4.8 and +6.5%) vs CON, with slightly greater relative increases than the overall effect of caffeine (+4.1%). Performance was not different between PLA and CON within subgroups (all P>0.05), although there was a tendency toward improved performance when participants believed they had ingested caffeine post-exercise (P=0.06; 87% likely beneficial). Participants who correctly identified placebo in PLA showed possible harmful effects on performance compared to CON. Supplement identification appeared to influence exercise outcome and may be a source of bias in sports nutrition. (AU)

FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/14746-4 - Carnosine metabolism in skeletal muscle: a multi-approach study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
Grantee:Vitor de Salles Painelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/19513-2 - Effects of chronic beta-alanine supplementation with and without acute sodium bicarbonate ingestion on peak muscle carnosine concentration, washout and high-intensity exercise performance
Grantee:Bryan Saunders
Support type: Scholarships in Brazil - Post-Doctorate