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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Factors affecting the periapical healing process of endodontically treated teeth

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Author(s):
Holland, Roberto [1] ; Gomes Filho, Joao Eduardo [1] ; Angelo Cintra, Luciano Tavares [1] ; de Azevedo Queiroz, India Olinta [1] ; Estrela, Carlos [2]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, Fac Odontol Aracatuba, Dept Odontol Restauradora, R Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Fed Goias, Fac Odontol, Dept Ciencias Estomatol, Goiania, Go - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Applied Oral Science; v. 25, n. 5, p. 465-476, SEP-OCT 2017.
Web of Science Citations: 11
Abstract

Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing. This review aims to discuss the important therapeutic factors associated with the clinical protocol used during root canal treatment and to highlight the systemic conditions associated with the periapical healing process of endodontically treated teeth. The antibacterial strategies indicated in the conventional treatment of an inflamed and infected pulp and the modulation of the host's immune response may assist in tissue repair, if wound healing has been hindered by infection. Systemic conditions, such as diabetes mellitus and hypertension, can also inhibit wound healing. The success of root canal treatment is affected by the correct choice of clinical protocol. These factors are dependent on the sanitization process (instrumentation, irrigant solution, irrigating strategies, and intracanal dressing), the apical limit of the root canal preparation and obturation, and the quality of the sealer. The challenges affecting the healing process of endodontically treated teeth include control of the inflammation of pulp or infectious processes and simultaneous neutralization of unpredictable provocations to the periapical tissue. Along with these factors, one must understand the local and general clinical conditions (systemic health of the patient) that affect the outcome of root canal treatment prediction. (AU)

FAPESP's process: 12/09987-0 - Biocompatibility and biomineralization assessment of experimental sealers Sealepox and Sealepox RP compared to Pro-Root MTA ®: histological and immunohistochemical study in the subcutaneous tissue of rats
Grantee:Luciano Tavares Angelo Cintra
Support type: Regular Research Grants
FAPESP's process: 12/06943-1 - Effect of raloxifene on periapical lesions in ovariectomized rats
Grantee:João Eduardo Gomes Filho
Support type: Regular Research Grants
FAPESP's process: 12/06785-7 - Influence of diferente irrigating solutions associated to photodinamic therapy: in vitro and in vivo study
Grantee:João Eduardo Gomes Filho
Support type: Regular Research Grants
FAPESP's process: 12/02083-8 - Influence of pulpal infection associated with diabetes in the blood profile and, quantification of proinflammatory cytokines TNF-±, IL-6, IL-17. Microscopic analysis, blood measurement and study in organs of rats.
Grantee:Luciano Tavares Angelo Cintra
Support type: Regular Research Grants
FAPESP's process: 12/01153-2 - Influence of Diabetes Mellitus on tissue response and ability to mineralization of Sealapex®, Angelus MTA and MTA Fillapex: histological study in rats
Grantee:João Eduardo Gomes Filho
Support type: Regular Research Grants