Dias, Carlos S. B.
Hanchuk, Talita D. M.
Shigeyosi, Willian T.
Rossi, Andre L.
Tanaka, Marcelo N.
Cardoso, Mateus B.
Total Authors: 9
 UNICAMP State Univ Campinas, Cidade Univ Zeferino Vaz, BR-13083970 Campinas, SP - Brazil
 LNLS Brazilian Synchrotron Light Source, Rua Giuseppe Maximo Scolfaro, 10000, BR-13083970 Campinas, SP - Brazil
 LNBio Brazilian Biosci Natl Lab, Rua Giuseppe Maximo Scolfaro, 10000, BR-13083970 Campinas, SP - Brazil
 UFMS Fed Univ Mato Grosso Sul, Cidade Univ, BR-79070900 Campo Grande - Brazil
 UFSCar Fed Univ Sao Carlos, Rodovia Washington Luis, Km 235, S-N, BR-13565905 Sao Carlos, SP - Brazil
 CBPF Brazilian Ctr Res Phys, Rua Doutor Xavier Sigaud, 150, BR-22290180 Rio De Janeiro - Brazil
 LNNano Brazilian Nanotechnol Natl Lab, Rua Giuseppe Maximo Scolfaro, 10000, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 7
NOV 1 2017.
Web of Science Citations:
This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field. Thereby, we demonstrate a new and efficient magnetic hyperthermia strategy in which a small, but well localized, concentration of VIPs can promote an intracellular hyperthermia process. (AU)