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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biosurfactants produced by Scheffersomyces stipitis cultured in sugarcane bagasse hydrolysate as new green larvicides for the control of Aedes aegypti, a vector of neglected tropical diseases

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Author(s):
Franco Marcelino, Paulo Ricardo [1] ; da Silva, Vinicius Luiz [2] ; Philippini, Rafael Rodrigues [1] ; Von Zuben, Claudio Jose [3] ; Contiero, Jonas [2] ; dos Santos, Julio Cesar [1] ; da Silva, Silvio Silverio [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, Lorena - Brazil
[2] Sao Paulo State Univ, Dept Biochem & Microbiol, Biosci Inst, Campus Rio Claro, Rio Claro - Brazil
[3] Sao Paulo State Univ, Dept Zool, Biosci Inst, Campus Rio Claro, Rio Claro - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PLoS One; v. 12, n. 11 NOV 10 2017.
Web of Science Citations: 5
Abstract

Biosurfactants are microbial metabolites with possible applications in various industrial sectors that are considered ecofriendly molecules. In recent years, some studies identified these compounds as alternatives for the elimination of vectors of tropical diseases, such as Aedes aegypti. The major bottlenecks of biosurfactant industrial production have been the use of conventional raw materials that increase production costs as well as opportunistic or pathogenic bacteria, which restrict the application of these biomolecules. The present study shows the potential of hemicellulosic sugarcane bagasse hydrolysate as a raw material for the production of a crystalline glycolipidic BS by Scheffersomyces stipitis NRRL Y-7124, which resulted in an emulsifying index (EI24) of 70 +/- 3.4% and a superficial tension of 52 +/- 2.9 mN.m(-1). Additionally, a possible new application of these compounds as biolarvicides, mainly against A. aegypti, was evaluated. At a concentration of 800 mg.L-1, the produced biosurfactant caused destruction to the larval exoskeletons 12 h after application and presented an letal concentration (LC50) of 660 mg.L-1. Thus, a new alternative for biosurfactant production using vegetal biomass as raw material within the concept of biorefineries was proposed, and the potential of the crystalline glycolipidic biosurfactant in larvicidal formulations against neglected tropical disease vectors was demonstrated. (AU)

FAPESP's process: 15/06238-4 - Biosurfactants as versatile molecules: a new concept of product for biorefineries and for action against neglected tropical diseases phase 1: screening of yeasts, fermentative production and physicochemical characterization
Grantee:Silvio Silvério da Silva
Support type: Regular Research Grants
FAPESP's process: 16/14852-7 - A sustainable solution against neglected tropical diseases using biosurfactants produced by yeasts in sugarcane bagasse hemicellulosic hydrolyzate
Grantee:Paulo Ricardo Franco Marcelino
Support type: Scholarships in Brazil - Post-Doctorate