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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Longitudinal study of lung function in pregnant women: Influence of parity and smoking

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Author(s):
Manfre Pastro, Luciana Duzolina [1] ; Lemos, Miriam [2] ; Arrabal Fernandes, Frederico Leon [3] ; Dias Medici Saldiva, Silvia Regina [4] ; Vieira, Sandra Elisabete [5] ; Saraiva Romanholo, Beatriz Mangueira [6, 7] ; Nascimento Saldiva, Paulo Hilario [2] ; Vieira Francisco, Rossana Pulcineli [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Med FMUSP, Dept Ginecol & Obstet, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med FMUSP, Dept Patol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Faculdade Medicina, Hosp Clin HCFMUSP, Inst Coracao InCor, Disciplina Pulmonol, Lab Funcao, Sao Paulo, SP - Brazil
[4] Secretaria Estado Saude Sao Paulo, Inst Saude, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Fac Med FMUSP, Dept Pediat, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Fac Med, Dept Med LIM 20, Sao Paulo, SP - Brazil
[7] Univ Cidade Sao Paulo UNICID, Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Clinics; v. 72, n. 10, p. 595-599, OCT 2017.
Web of Science Citations: 2
Abstract

OBJECTIVES: To evaluate pulmonary function in the first and third trimesters of pregnancy and analyze the influence of parity and smoking on spirometry parameters. METHODS: This longitudinal prospective study included a cohort of 120 pregnant women. The inclusion criteria were as follows: singleton pregnancy, gestational age less than 13.86 weeks, and no preexisting maternal diseases. The exclusion criteria were as follows: change of address, abortion, and inadequate spirometry testing. ClinicalTrials. gov: NCT02807038. RESULTS: A decrease in values of forced vital capacity and forced expiratory volume were noted in the first second from the first to third trimester. In the first and third trimesters, multiparous women demonstrated lower absolute forced vital capacity and forced expiratory volume values in the first second compared with nulliparous women (p < 0.0001 and p=0.001, respectively). Multiparous women demonstrated reduced forced expiratory flow in 25% to 75% of the maneuver compared with nulliparous women in the first (p=0.005) and third (p=0.031) trimesters. The absolute values of forced expiratory flow in 25% to 75%, forced expiratory volume in the first second and predicted peak expiratory flow values in the third trimester were higher in smokers compared with nonsmokers (p=0.042, p=0.039, p=0.024, and p=0.021, respectively). CONCLUSION: There was a significant reduction in forced vital capacity and forced expiratory volume values in the first second during pregnancy. Parity and smoking significantly influence spirometric variables. (AU)

FAPESP's process: 09/17315-9 - Influence of nutritional factors and urban air pollutants on children's respiratory health: cohort study in pregnant women in São Paulo
Grantee:Silvia Regina Dias Medici Saldiva
Support type: Regular Research Grants