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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

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Matsuzaka, Camila T. [1] ; Christofolini, Denise [2] ; Ota, Vanessa K. [3, 1, 4] ; Gadelha, Ary [1, 4] ; Berberian, Arthur A. [1, 4, 5] ; Noto, Cristiano [1, 4] ; Mazzotti, Diego R. [6] ; Spindola, Leticia M. [3, 1, 4] ; Moretti, Patricia N. [3, 1, 4] ; Smith, Marilia A. C. [3] ; Melaragno, Maria I. [3] ; Belangero, Sintia I. [3, 1, 4] ; Bressan, Rodrigo A. [1, 4]
Total Authors: 13
[1] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo, SP - Brazil
[2] FMABC, Dept Saude Colet, Santo Andre, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Morfol & Genet, Disciplina Genet, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo, SP - Brazil
[5] Ctr Univ Fundcao Inst Ensino Osasco UNIFIEO, Dept Psicol Educ, Osasco, SP - Brazil
[6] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 39, n. 4, p. 302-308, OCT-DEC 2017.
Web of Science Citations: 7

Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks. For genetic association analyses, 212 individuals with schizophrenia and 257 healthy controls (HCs) were selected. The Visual Working Memory (VWM) Task, Keep Track Task, and Letter Memory Task were administered to 133 schizophrenics and 93 HCs. Results: We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia. COMT rs4680 AA carriers and rs737865 AA carriers scored lowest on the Keep Track Task. When the genotype{*} group interaction effect was evaluated, rs165599 exerted opposite effects for VWM and Keep Track task performance in patients and controls, with AA carriers scoring lowest on both tests among controls, but highest among patients. Conclusion: These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls. (AU)

FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants