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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ascorbic acid supplementation partially prevents the delayed reproductive development in juvenile male rats exposed to rosuvastatin since prepuberty

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Author(s):
Araujo Leite, Gabriel Adan [1] ; Figueiredo, Thamiris Moreira [2] ; Sanabria, Marciana [2] ; Mota Goncalves Dias, Ana Flavia [2] ; Villela e Silva, Patricia [2] ; Martins Junior, Airton da Cunha [3] ; Barbosa Junior, Fernando [3] ; Kempinas, Wilma De Grava [2]
Total Authors: 8
Affiliation:
[1] State Univ Campinas UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REPRODUCTIVE TOXICOLOGY; v. 73, p. 328-338, OCT 2017.
Web of Science Citations: 6
Abstract

Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. This study aimed to evaluate whether ascorbic acid supplementation may prevent the reproductive damage provoked by rosuvastatin administration at prepuberty. Male pups were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 150 mg/day of ascorbic acid associated with 3 or 10 mg/kg/day of rosuvastatin from post-natal day (PND) 23 until PND53. Rosuvastatin-treated groups showed delayed puberty installation, androgen depletion and impairment on testicular and epididymal morphology. Ascorbic acid partially prevented these reproductive damages. In conclusion, rosuvastatin exposure is a probable risk to reproductive development and ascorbic acid supplementation may be useful to prevent the reproductive impairment of rosuvastatin exposure. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/22495-1 - Male rats exposed to rosuvastatin during prepuberty in the absence or presence of vitamin C: immediate and late effects on genital system and the fertility of generations F0 and F1
Grantee:Gabriel Adan Araújo Leite
Support Opportunities: Scholarships in Brazil - Doctorate