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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral cancer stem cells - properties and consequences

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Camila Oliveira Rodini ; Nathália Martins Lopes ; Vanessa Soares Lara ; Ian Campbell Mackenzie
Total Authors: 4
Document type: Journal article
Source: Journal of Applied Oral Science; v. 25, n. 6, p. -, Dez. 2017.

Abstract Research on cancer stem cells (CSCs) has greatly increased in the field of medicine and pathology; however, some conceptual misunderstandings are still present among the public as well as within the general scientific community that is not yet familiar with the subject. The very first problem is the misinterpretation of CSCs as a synonym of their normal counterparts, the well-known stem cells (SCs). Particularly in Dentistry, another common mistake is the misinterpretation of oral CSCs as normal tooth-derived SCs. The present review aims to clarify important concepts related to normal SCs and CSCs, as well as discuss the relevance of CSCs to the development, metastasis and therapy resistance of oral squamous cell carcinoma. (AU)

FAPESP's process: 15/00101-7 - Study of the relative frequency and participation of cancer stem cells subpopulations in the process of metastasis of oral squamous cell carcinoma
Grantee:Nathália Martins Lopes
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/07245-9 - Investigation of the role of cancer stem cells and microenvironment on epithelial-to-mesenchymal transition, invasion and metastasis in oral squamous cell carcinoma
Grantee:Camila de Oliveira Rodini Pegoraro
Support type: Research Grants - Young Investigators Grants