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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metabolism studies of chiral pesticides: A critical review

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Author(s):
Perez de Albuquerque, Nayara Cristina [1] ; Carrao, Daniel Blascke [1] ; Habenschus, Maisa Daniela [1] ; Moraes de Oliveira, Anderson Rodrigo [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Journal of Pharmaceutical and Biomedical Analysis; v. 147, n. SI, p. 89-109, JAN 5 2018.
Web of Science Citations: 34
Abstract

The consumption of pesticides worldwide has been growing in recent decades, and consequently the exposure of humans and other animals to them as well. However, even though it is known that chiral pesticides can behave stereoselectively, the knowledge about the risks to human health and the environment is scarce. Among the pesticides registered to date, approximately 30% have at least one center of asymmetry, and just 7% of them are currently marketed as a pure stereoisomer or as an enriched mixture of the active stereoisomer. There are several in vitro, in vivo, and in silico models available to evaluate the enantioselective metabolism of chiral pesticides aiming ecotoxicological and risk assessment. Therefore, this paper intends to provide a critical view of the metabolism of chiral pesticides in non-target species, including humans, and discuss their implications, as well as, conduct a review of the analytical techniques employed for in vitro and in vivo metabolism studies of chiral pesticides. (C) 2017 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 16/07597-0 - Development of chromatographic/electrophoretic methods to be further used in in vitro enzymatic inhibition and drug interaction of chiral pesticides
Grantee:Anderson Rodrigo Moraes de Oliveira
Support type: Regular Research Grants
FAPESP's process: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies
Grantee:Maria Valnice Boldrin
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/15680-5 - Enantioselective in vitro studies of metabolism, enzymatic inhibition and toxicity of the pesticide fipronil
Grantee:Daniel Blascke Carrão
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/02533-1 - In vitro enantioselective studies of metabolism , cytotoxicity and genotoxicity of the nematicide fenamiphos
Grantee:Nayara Cristina Perez de Albuquerque
Support type: Scholarships in Brazil - Doctorate