| Full text | |
| Author(s): |
Gisele A. B. Canuto
[1]
;
José Luiz da Costa
[2]
;
Pedro L. R. da Cruz
[3]
;
Ana Rosa L. de Souza
[4]
;
Andréa T. Faccio
[5]
;
Aline Klassen
[6]
;
Karina T. Rodrigues
[7]
;
Marina F. M. Tavares
[8]
Total Authors: 8
|
| Affiliation: | [1] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[2] Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas. Centro de Controle de Intoxicações - Brasil
[3] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[4] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[5] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[6] Universidade Federal de São Paulo. Departamento de Química - Brasil
[7] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
[8] Universidade de São Paulo. Instituto de Química. Departamento de Química Fundamental - Brasil
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Química Nova; v. 41, n. 1, p. 75-91, 2018-01-00. |
| Abstract | |
Metabolomics is an emerging and promising omics approach used to understand biological mechanisms. By untargeted and targeted metabolomics analyses, metabolites are determined in biological samples (fluids, cells, tissues, etc.) by comparison of control groups with altered groups, undergoing different therapies, submitted to differing stress levels, dietary modulation, or promoted by a disease, or specific condition, etc., using sophisticated analytical techniques, and advanced data treatment and statistical analyses. In this review, the concepts involved in metabolomics studies were presented, describing in details all steps involved in the metabolomics workflow, for untargeted and targeted strategies. Finally, the potential of metabolomics is illustrated by applications in representative areas: clinical, environmental, food and nutrition, forensic toxicology, microbiology, parasitology, plants, and sports. Relevant reviews were compiled to characterize each of these areas, and a corresponding application of untargeted and targeted metabolomics were described. (AU) | |
| FAPESP's process: | 15/10650-8 - Stability of medicines, drugs of abuse and pesticides in dried blood spots (DBS), and its application in forensic toxicology |
| Grantee: | José Luiz da Costa |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/07361-6 - Mobility modulation in capillary electrophoresis |
| Grantee: | Marina Franco Maggi Tavares |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/09822-0 - Evaluation of urinary global fingerprint of vesicoureteral reflux for CE-MS |
| Grantee: | Karina Trevisan Rodrigues |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/51692-7 - Role of adaptative immunity on the progress of ischemic heart disease after acute myocardial infarction |
| Grantee: | Francisco Antonio Helfenstein Fonseca |
| Support Opportunities: | Research Projects - Thematic Grants |