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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chrysin Administration Protects against Oxidative Damage in Varicocele-Induced Adult Rats

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Missassi, Gabriela [1, 2] ; Borges, Cibele dos Santos [1] ; Rosa, Josiane de Lima [1] ; Villela e Silva, Patricia [1] ; Martins, Jr., Airton da Cunha [3] ; Barbosa, Jr., Fernando [3] ; Kempinas, Wilma De Grava [1]
Total Authors: 7
[1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
[2] Univ Campinas UNICAMP, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Analyses Toxicol & Food Sci, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavage with 50 mg/kg/day of chrysin (V1), or vehicle (V2) for 56 days. Chrysin treatment prevented oxidative damage resulting from varicocele by decreasing testicular concentrations of malondialdehyde and sperm DNA fragmentation. It also improved histological aspect of the testis and maintained morphometric parameters similar to the sham group. Furthermore, there were no differences in body and reproductive organ weights, histopathological analysis of epididymis, sperm counts and morphology, testosterone levels, sexual behavior, and fertility parameters among experimental groups. Our results reinforce the idea that injuries provoked by experimental varicocele are related, at least in part, to oxidative stress. Moreover, varicocele showed bilateral deleterious effects without interfering with fertility. Chrysin administration significantly ameliorated sperm parameters, protecting the reproductive system against varicocele damages. For that reason, chrysin might be an alternative adjuvant therapy to improve sperm quality in men presenting this condition. (AU)

FAPESP's process: 15/26309-3 - Reproductive outcomes of antioxidant therapy with chrysin in experimental varicocele in rats
Grantee:Gabriela Missassi
Support type: Scholarships in Brazil - Master