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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis

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Quintar, Amado A. [1] ; Goncalves, Bianca F. [2] ; Taboga, Sebastiao R. [2] ; Maldonado, Cristina A. [1]
Total Authors: 4
[1] Univ Nacl Cordoba, Fac Ciencias Med, Inst Invest Ciencias Salud INICSA CONICET, Ctr Microscopia Elect, Cordoba - Argentina
[2] Univ Estadual Paulista UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Cell Biology International; v. 41, n. 11, SI, p. 1234-1238, NOV 2017.
Web of Science Citations: 1

One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studies for prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on N-methyl-N-nitrosourea (MNU)-induced prostate carcinogenesis in gerbils. Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate. Furthermore, chronic bacterial inflammation itself induced premalignant lesions in the ventral lobe and increased their frequency in the dorsolateral lobe as well as malignant lesions in the ventral prostate. These animals showed a rich inflammatory microenvironment, characterized as intraluminal and periductal foci. These data indicate that chronic inflammation induced by Escherichia coli acts as a potent tumor promoter, in the early stages of carcinogenesis in the gerbil, in line with the hypothesis of inflammation supporting several steps of tumor development in the prostate gland. (AU)

FAPESP's process: 14/26660-0 - Study of prostatic reactive stroma after bilateral orchiectomy and subsequent inhibition of aromatase activity by chrysin and inhibition of 5-alpha reductase activity by Finasteride
Grantee:Sebastião Roberto Taboga
Support type: Regular Research Grants