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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty

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Author(s):
Araujo Leite, Gabriel Adan [1, 2] ; Figueiredo, Thamiris Moreira [2] ; Pacheco, Taina Louise [2] ; Sanabria, Marciana [2] ; Villela e Silva, Patricia [2] ; Fernandes, Fabio Henrique [3] ; Kempinas, Wilma De Grava [2]
Total Authors: 7
Affiliation:
[1] State Univ Campinas UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil
[2] Sao Paulo State Univ Unesp, Dept Morphol, Inst Biosci, Botucatu, SP - Brazil
[3] Sao Paulo State Univ Unesp, Grad Program Genet, Inst Biosci, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Food and Chemical Toxicology; v. 109, n. 1, p. 272-283, NOV 2017.
Web of Science Citations: 4
Abstract

Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/13659-3 - Short and long-term effects of the exposure to rosuvastatin, in the presence or absence of Vitamin C, during prepuberty, on the rat male reproductive system
Grantee:Thamiris Moreira Figueiredo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/22495-1 - Male rats exposed to rosuvastatin during prepuberty in the absence or presence of vitamin C: immediate and late effects on genital system and the fertility of generations F0 and F1
Grantee:Gabriel Adan Araújo Leite
Support type: Scholarships in Brazil - Doctorate