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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sorting permutations and binary strings by length-weighted rearrangements

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Author(s):
Lintzmayer, Carla Negri [1] ; Fertin, Guillaume [2] ; Dias, Zanoni [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Inst Comp, Campinas, SP - Brazil
[2] Univ Nantes, UMR CNRS 6004, LS2N, Nantes - France
Total Affiliations: 2
Document type: Journal article
Source: THEORETICAL COMPUTER SCIENCE; v. 715, p. 35-59, MAR 8 2018.
Web of Science Citations: 0
Abstract

Comparative genomics is a line of study which aims at determining dis/similarities between genomes. One way of doing this is to infer the large scale mutations (also called genome rearrangements) that are responsible for transforming one genome into another, under the parsimony principle. Numerous efforts have been made over the past years regarding the traditional approach, in which all genome rearrangements have the same unit cost. However, since long rearrangements are more likely to disturb the organism, some works considered the length-weighted approach, in which the cost of each rearrangement is a function of its length. The problem is thus modeled as follows: given two genomes G(1) and G(2) and a set beta of allowed genome rearrangements, each with a given cost, determine their distance, i.e., the total cost of a minimum-cost sequence of rearrangements from beta that transforms G(1) into G(2). In this paper, we study length-weighted reversals and transpositions, mainly considering their prefix variants (in which the leftmost part of the genome must always be included). We present approximation algorithms and bounds on the distances and diameters (i.e., maximum possible distance over any two genomes of same length) for eight problems when genomes are represented as permutations, and another eight problems when genomes are represented as binary strings, in each case considering two different cost functions. (C) 2018 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/20738-7 - Sorting permutations by prefix reversals and suffix reversals
Grantee:Carla Negri Lintzmayer
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 14/19401-8 - Genome rearrangement algorithms
Grantee:Zanoni Dias
Support type: Regular Research Grants
FAPESP's process: 13/01172-0 - The sorting permutations problem using prefix and suffix operations
Grantee:Carla Negri Lintzmayer
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/11937-9 - Investigation of hard problems from the algorithmic and structural stand points
Grantee:Flávio Keidi Miyazawa
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/08293-7 - CCES - Center for Computational Engineering and Sciences
Grantee:Munir Salomao Skaf
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC