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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral shedding of human herpesviruses in renal transplant recipients

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de Santana Sarmento, Dmitry Jose [1] ; Tozetto-Mendoza, Tania Regina [2] ; Sumita, Laura Masami [2] ; Pierroti, Ligia Camara [3] ; Pallos, Debora [4] ; Caliento, Rubens [1] ; Palmieri, Michelle [1] ; de Oliveira Martins, Victor Adriano [1] ; Gallottini, Marina [1] ; Pannuti, Claudio Sergio [2] ; Braz-Silva, Paulo Henrique [1, 2]
Total Authors: 11
[1] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Pathol, Ave Prof Lineu Prestes 2227, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Trop Med, Virol Lab, Ave Dr Eneas de Carvalho Aguiar, 470 Jd Amer, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Infect Dis, Ave Dr Arnaldo, 455 Cerqueira Cesar, Sao Paulo, SP - Brazil
[4] Univ Santo Amaro, Dept Dent, Rua Prof Eneas de Siqueira Neto, 340 Santo Amaro, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 22, n. 2, p. 885-891, MAR 2018.
Web of Science Citations: 4

To describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients. This is a prospective case-control study of 50 renal transplant recipients and control group of 50 individuals (non-transplanted and immunocompetent). Mouthwash samples were collected via oral rinse and then submitted to screening for the presence of eight types of herpesviruses by using multiplex PCR. Fisher's exact, chi-square, and Student t tests were used for statistical analysis, and the significance level was set at 5%. The mean age of the study group was 49.42 +/- 12.94 years, 28/50 (56%) were female, and the time elapsed after transplantation was 68.20 +/- 67.19 months. Herpes simplex virus 1 (HSV-1) (P = 0.025) and Epstein-Barr virus (EBV) (P = 0.024) were, statistically, more excreted in the saliva of renal transplant recipients compared to control group. Gender (P = 1.00) and age (P = 0.563) did not influence the salivary shedding of herpesviruses in renal transplant recipients. Individuals who excreted varicella-zoster virus in saliva had a shorter mean time of transplantation (22:00 + 2.82 months) (P < 0.001). Renal transplant recipients excreted herpesviruses more often than controls, especially HSV-1 and EBV, with salivary shedding of herpesviruses being more frequent in patients with recent kidney transplantation. The present findings support other longitudinal studies evaluating the relationship between oral shedding of human herpesviruses and clinical presence of active infection and renal transplant failure. (AU)

FAPESP's process: 13/08242-3 - Detection of human herpesvirus in human saliva and gingival fluid of patients with chronic renal failure
Grantee:Débora Pallos
Support Opportunities: Regular Research Grants
FAPESP's process: 15/03906-6 - Herpesvirus oral shedding in oral mucosa of patients under radiotherapy to oral squamous cell Carcinoma of the head and neck treatment
Grantee:Victor Adriano de Oliveira Martins
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/04223-1 - HHV-8 oral shedding and viremia in HIV positive and negative patients
Grantee:Claudio Sergio Pannuti
Support Opportunities: Regular Research Grants