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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

PDCD1 gene polymorphisms as regulators of T-lymphocyte activity in cutaneous melanoma risk and prognosis

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Gomez, Gabriela V. B. [1] ; Rinck-Junior, Jose A. [1] ; Oliveira, Cristiane [1] ; Silva, Dennis H. L. [2] ; Mamoni, Ronei L. [2] ; Lourenco, Gustavo J. [3] ; Moraes, Aparecida M. [1] ; Lima, Carmen S. P. [1]
Total Authors: 8
[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Clin Oncol Serv, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Dept Clin Pathol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Lab Canc Genet, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PIGMENT CELL & MELANOMA RESEARCH; v. 31, n. 2 MAR 2018.
Web of Science Citations: 3

This study aimed to evaluate whether PD1.1 (c.-606G>A), PD1 (c.627 + 252C>T), PD1.5 (c.804C>T), and PD1.9 (c.644C>T) single nucleotide polymorphisms of PDCD1 gene influence the risk, clinicopathological aspects, and survival of cutaneous melanoma (CM). Individuals with phototype I or II and PD1 CC genotype were under 5.89-fold increased risk of developing CM. PD1.5 TT genotype increased PDCD1 expression (2.49 versus 1.28 arbitrary units, p = .03) and PD1.5 CT or TT genotype and allele T increased PD1 expression in TCD4(+) lymphocytes (16.6 versus 12.5%, p = .01; 17.0 versus 13.1%, p = .006). At 60 months of follow-up, short recurrence-free survival was seen in patients with PD1.1 AA genotype (33.3 versus 71.8%, p = .03). Patients with PD1.1 AA and PD1.5 CC genotype had 4.21 and 2.62 more chances of presenting relapse and evolving death by disease in Cox analyses, respectively. Our data provide preliminary evidence that abnormalities in regulation of T lymphocyte alter CM risk, clinical aspects, and prognosis. (AU)

FAPESP's process: 14/10042-5 - Influence of the PDCD1 polymorphisms, related to activity of T lymphocytes, in gene expression and susceptibility to cutaneous melanoma
Grantee:Gabriela Vilas Bôas Gomez
Support type: Scholarships in Brazil - Master