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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Upregulation of Ghrelin Gene Expression in the Excluded Stomach of Obese Women with Type 2 Diabetes After Roux-en-Y Gastric Bypass in the SURMetaGIT Study

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Author(s):
Fonseca, Danielle Cristina [1] ; Sala, Priscila [1] ; Singer, Joelle [2, 3] ; Singer, Pierre [2, 3] ; Torrinhas, Raquel Susana [1] ; Waitzberg, Dan Linetzky [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Med FMUSP, Lab Metanutri LIM 35, Dept Gastroenterol, Sao Paulo, SP - Brazil
[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv - Israel
[3] Belinson Hosp, Rabin Med Ctr, Endocrine Inst, Jabotinski St, Petah Tiqwa - Israel
Total Affiliations: 3
Document type: Journal article
Source: OBESITY SURGERY; v. 28, n. 3, p. 877-880, MAR 2018.
Web of Science Citations: 3
Abstract

Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones. The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr. In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin. After RYGB, GHRL expression increased in the excluded stomach (p < 0.05) with no change in other gastrointestinal sites. There were no significant changes in ghrelin plasma levels and no correlations with T2Dr. After RYGB, over-expression of GHRL gene occurs only in the excluded stomach with no correlation to T2Dr. (AU)

FAPESP's process: 13/03246-0 - Genomic, proteomic and metabolomic study of gastrointestinal tissue for patients with type 2 Diabetes mellitus after Roux-en-Y gastric bypass
Grantee:Priscila Sala Kobal
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass
Grantee:Dan Linetzky Waitzberg
Support Opportunities: Research Projects - Thematic Grants