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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma

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Author(s):
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Oliveira, Denise Tostes [1] ; Bravo-Calderon, Diego Mauricio [1] ; Lauand, Gustavo Amaral [1] ; Assao, Agnes [1] ; Suarez-Penaranda, Jose-Manuel [2, 3] ; Perez-Sayans, Mario [4] ; Garcia-Garcia, Abel [4] ; Marana, Aparecido Nilceu [5] ; Nonogaki, Suely [6] ; Pereira Lauris, Jose Roberto [7] ; Kowalski, Luiz Paulo [8]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Area Pathol, BR-17012901 Bauru, SP - Brazil
[2] Univ Hosp, Dept Pathol & Forens Sci, Santiago De Compostela 15706, Galicia - Spain
[3] Sch Med Santiago de Compostela, Santiago De Compostela 15706, Galicia - Spain
[4] Clin Hosp Univ Santiago, Inst Res Santiago de Compostela IDIS, Fac Med & Dent, Santiago De Compostela 15782, A Coruna - Spain
[5] Sao Paulo State Univ UNESP, Fac Sci, Dept Comp, BR-17033360 Bauru, SP - Brazil
[6] Adolfo Lutz Inst, Div Pathol, BR-01246902 Sao Paulo, SP - Brazil
[7] Univ Sao Paulo, Bauru Sch Dent, Dept Community Dent, BR-17012901 Bauru, SP - Brazil
[8] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509010 Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: JOURNAL OF ONCOLOGY; 2016.
Web of Science Citations: 0
Abstract

Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (beta 2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with beta 2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of beta 2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of beta 2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (p = 0.383; p = 0.002). The immunohistochemical distribution of beta 2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of beta 2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive. (AU)

FAPESP's process: 12/04098-2 - Expression of beta-2 adrenergic receptor in frozen tissues of the oral squamous cell carcinomas
Grantee:Gustavo Amaral Lauand
Support type: Scholarships abroad - Research Internship - Scientific Initiation
FAPESP's process: 11/11630-0 - Comparison of beta-2-adrenergic receptor in the surgical margins of oral mucosa and malignant cells of oral squamous cell carcinoma
Grantee:Gustavo Amaral Lauand
Support type: Scholarships in Brazil - Scientific Initiation