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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Repeated Domperidone treatment modulates pulmonary cytokines in LPS-induced acute lung injury in mice

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Author(s):
Barreto, Talita Rossetto [1] ; Costola-de-Souza, Carolina [1] ; Margatho, Rafael Oliveira [1] ; Queiroz-Hazarbassanov, Nicolle [1] ; Rodrigues, Sandra Campos [1] ; Felicio, Luciano Freitas [1] ; Palermo-Neto, Joao [1] ; Zager, Adriano [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Neuroimmunomodulat Res Grp, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: International Immunopharmacology; v. 56, p. 43-50, MAR 2018.
Web of Science Citations: 6
Abstract

The dopaminergic antagonist drug Domperidone has immunomodulatory effects. We investigated the effects of repeated Domperidone treatment in a model of Lypopolyssacharide (LPS)-induced acute lung inflammation. Adult C57BL/6J mice were treated with either Vehicle or Domperidone for 5 days, and challenged intranasally with LPS in the following day. The behavior of mice was analyzed in the open field and elevated plus-maze test before and 24 h after LPS challenge. The bronchoalveolar lavage fluid, blood and lung tissue were collected 24 h and 48 h after LPS challenge. Domperidone treatment increased LPS-induced tumor necrosis factor (TNF) and interleukin (IL)-6 production in the bronchoalveolar lavage fluid, without altering tissue damage and the number of immune cells in the lungs and circulation. Locomotor and anxiety-like behavior were unchanged after Domperidone and/or LPS treatment. Cytokine data indicate that Domperidone promotes a change in activity of other cell types, likely alveolar epithelial cells, without affecting immune cell migration in the present model. Due to the role of these cytokines in progression of inflammation, Domperidone treatment may exacerbate a subsequent inflammatory injury. (AU)

FAPESP's process: 15/02441-0 - Effects of hyperprolactinemia in a murine model of acute pulmonary inflammation
Grantee:Talita Rossetto Barreto
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/18921-5 - Effects of modafinil on immunity, neuroinflammation and development of experimental autoimmune encephalomyelitis in mice
Grantee:Adriano Zager
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships
Grantee:João Palermo Neto
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/22364-2 - Hyperprolactinemia and allergic inflammatory response of the lungs
Grantee:Luciano Freitas Felicio
Support type: Regular Research Grants