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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Release and permeation profiles of spray-dried chitosan microparticles containing caffeic acid

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Author(s):
Spagnol, Caroline Magnani [1] ; Melero Zaera, Ana [2] ; Borges Isaac, Vera Lucia [1] ; Correa, Marcos Antonio [1] ; Nunes Salgado, Herida Regina [3]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Lab Cosmetol, Dept Drugs & Med, Araraquara, SP - Brazil
[2] Univ Valencia, Dept Pharm Pharmaceut Technol & Parasitol, Valencia - Spain
[3] Sao Paulo State Univ UNESP, Dept Drugs & Med, Qual Control Lab, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SAUDI PHARMACEUTICAL JOURNAL; v. 26, n. 3, p. 410-415, MAR 2018.
Web of Science Citations: 5
Abstract

Caffeic acid (CA), a phenolic compound found in plants with antioxidant and antimicrobial activity, induces collagen production and prevents premature aging of the skin. The objective of this study was to develop two types of chitosan microparticles (MP) containing CA and to relate the morphology with the release and permeation profiles. One type of MP was prepared from a hydroalcoholic solution (MPI) and the other from an aqueous solution (MPII). Their morphology and size was evaluated by high-resolution scanning electron microscopy. The release profile of CA was evaluated using the cellulose membrane from the two MPs in Franz diffusion cells and the permeation profile was evaluated using human abdominal skin samples; the epidermal membranes were prepared by the heat-separation technique. MPII was spherical with a smooth surface, suitable for the controlled release of substances, whereas MPI was porous with non-internalized residual material. This result was consistent with their release and permeation profiles because MPII exhibited a slower and more controlled release than MPI. Thus, the method of preparation of MP and their composition influence the release profile of CA. Therefore, the production conditions must be closely controlled. (C) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license. (AU)

FAPESP's process: 16/06742-7 - Release and permeation studies of topical formulations containing caffeic acid.
Grantee:Caroline Magnani Spagnol
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/02619-3 - Biodegradable polymeric microparticles containing caffeic acid for dermal application
Grantee:Caroline Magnani Spagnol
Support type: Scholarships in Brazil - Doctorate