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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mirror Neurons Modeled Through Spike-Timing-Dependent Plasticity are Affected by Channelopathies Associated with Autism Spectrum Disorder

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Author(s):
Antunes, Gabriela [1] ; Faria da Silva, Samuel F. [2] ; Simoes de Souza, Fabio M. [3]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Phys, Ribeirao Preto, SP - Brazil
[2] Pontificia Univ Catolica Campinas, Campinas, SP - Brazil
[3] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Neural Systems; v. 28, n. 5, SI JUN 2018.
Web of Science Citations: 8
Abstract

Mirror neurons fire action potentials both when the agent performs a certain behavior and watches someone performing a similar action. Here, we present an original mirror neuron model based on the spike-timing-dependent plasticity (STDP) between two morpho-electrical models of neocortical pyramidal neurons. Both neurons fired spontaneously with basal firing rate that follows a Poisson distribution, and the STDP between them was modeled by the triplet algorithm. Our simulation results demonstrated that STDP is sufficient for the rise of mirror neuron function between the pairs of neocortical neurons. This is a proof of concept that pairs of neocortical neurons associating sensory inputs to motor outputs could operate like mirror neurons. In addition, we used the mirror neuron model to investigate whether channelopathies associated with autism spectrum disorder could impair the modeled mirror function. Our simulation results showed that impaired hyperpolarization-activated cationic currents (Ih) affected the mirror function between the pairs of neocortical neurons coupled by STDP. (AU)

FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/08481-0 - Computational modeling of the postsynaptic mechanisms of the dopaminergic and glutamatergic integration in a hippocampal dendritic spine in health and pathological conditions
Grantee:Gabriela Antunes
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/18825-4 - Computing language with mirror neurons
Grantee:Fábio Marques Simões de Souza
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE