Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genomic characterisation of Leptospira inadai serogroup Lyme isolated from captured rat in Brazil and comparative analysis with human reference strain

Full text
Moreno, Luisa Z. [1] ; Miraglia, Fabiana [2] ; Loureiro, Ana P. [2] ; Kremer, Frederico S. [3] ; Eslabao, Marcus R. [3] ; Dellagostin, Odir A. [3] ; Lilenbaum, Walter [2] ; Vasconcellos, Silvio A. [1] ; Heinemann, Marcos B. [1] ; Moreno, Andrea M. [1]
Total Authors: 10
[1] Univ Sao Paulo, Fac Med Vet & Zootecn, Lab Epidemiol Mol & Resistencia Antimicrobianos, Sao Paulo, SP - Brazil
[2] Univ Fed Fluminense, Dept Microbiol & Parasitol, Lab Bacteriol Vet, Niteroi, RJ - Brazil
[3] Univ Fed Pelotas, Ctr Desenvolvimento Tecnol, Pelotas, RS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 113, n. 5 2018.
Web of Science Citations: 0

Leptospira inadai is classified as a species of the Leptospira intermediate group that has been poorly studied due to its apparent insignificance to human and animal health. Nevertheless, over the last two decades the species has been described in human cases in India and in carrier animals in Ecuador. Here, we present the first identification and genomic characterisation of L. inadai serogroup Lyme isolated from captured rodent in Brazil. Even though the M34/99 strain was not pathogenic for hamsters, it was able to establish renal colonisation. The M34/99 strain presented high similarity with L. inadai serogroup Lyme human reference indicating that animal strain could also infect humans, although it does not represent high risk of severe disease. An extrachromosomal sequence was also identified in M34/99 strain and presented high identity with previously described L. inadai phage LinZ\_10, suggesting that phage-like extrachromosomal sequence may be another feature of this understudied species. (AU)

FAPESP's process: 13/17136-2 - Characterization of Leptospira strains isolated in Brazil by Pulsed Field Gel Electrophoresis (PFGE) typing and comparative genomic analysis
Grantee:Luisa Zanolli Moreno
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/18290-0 - Characterization of Leptospira strains isolated in Brazil through multiloccus sequence typing (MLST)
Grantee:Andrea Micke Moreno
Support type: Regular Research Grants