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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor

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Moraes, Gabriel da Cunha [1] ; Vitoretti, Luana Beatriz [1] ; de Brito, Aurileia Aparecida [1] ; Alves, Cintia Estefano [1] ; Rigonato de Oliveira, Nicole Cristine [1] ; Dias, Alana dos Santos [2] ; Teles Matos, Yves Silva [1] ; Oliveira-Junior, Manoel Carneiro [3] ; Franco Oliveira, Luis Vicente [3] ; da Palma, Renata Kelly [3] ; Candeo, Larissa Carbonera [1] ; Lino-dos-Santos-Franco, Adriana [1] ; Ratto Tempestine Horliana, Anna Carolina [1] ; Gimenes, Joao Antonio Junior [4] ; Aimbire, Flavio [5] ; Vieira, Rodolfo Paula [2, 6, 7] ; Ligeiro-de-Oliveira, Ana Paula [1]
Total Authors: 17
Affiliation:
[1] Univ Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo, SP - Brazil
[2] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Jose Dos Campos, SP - Brazil
[3] Univ Nove Julho UNINOVE, Masters Degree & PhD Program Rehabil Sci, Expt Cardioresp Physiol Lab, Sao Paulo, SP - Brazil
[4] Univ Calif San Diego UCSD Hlth Sci, Div Trauma Surg Crit Care Burns & Acute Care Surg, Dept Surg, San Diego, CA - USA
[5] Fed Univ Sao Paulo UNIFESP, Inst Sci & Technol, Sao Jose Dos Campos, SP - Brazil
[6] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Santos, SP - Brazil
[7] Univ Brasil, Postgrad Program Bioengn, Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY; 2018.
Web of Science Citations: 2
Abstract

Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces. COPD is in the top five leading causes of deaths worldwide and presents a high economic cost. However, there are some preventive measures to lower the risk of developing COPD. Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects. So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD. C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day). After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm(2)) for 15 days and euthanized for morphologic and functional analysis of the lungs. Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1 beta, IL-6, and TNF-alpha in bronchoalveolar lavage fluid (BALF). We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor. On the other hand, LLLT increased the IL-10 release. Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD. (AU)

FAPESP's process: 15/23152-6 - Effect of low level laser therapy (LLLT) in an experimental model of pulmonary allergic inflammation induced house dust mite (HDM): study of dosimetry
Grantee:Nicole Cristine Rigonato de Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/13486-4 - Effect of low-level laser therapy on pulmonary inflammation in an experimental model of chronic obstructive pulmonary disease (COPD) induced by cigarette smoking: laser dosimetry studies
Grantee:Cintia Estefano Alves
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite
Grantee:Manoel Carneiro de Oliveira Junior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/16498-5 - Effect of low level laser therapy in experimental models of pulmonary chronic diseases
Grantee:Ana Paula Ligeiro de Oliveira
Support type: Research Grants - Young Investigators Grants