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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical Composition and Bioactivity of Essential Oil from Blepharocalyx salicifolius

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Furtado, Fabiana Barcelos [1] ; Borges, Bruna Cristina [2] ; Teixeira, Thaise Lara [2] ; Garces, Hans Garcia [3] ; de Almeida Junior, Luiz Domingues [4] ; Bergamo Alves, Fernanda Cristina [1] ; da Silva, Claudio Vieira [2] ; Fernandes Junior, Ary [1]
Total Authors: 8
[1] Unesp Sao Paulo State Univ, Lab Bacteriol, Inst Biosci Botucatu, BR-18618000 Botucatu, SP - Brazil
[2] Univ Fed Uberlandia, Inst Biomed Sci, Trypanosomatids Lab LATRI, BR-38400902 Uberlandia, MG - Brazil
[3] Unesp Sao Paulo State Univ, Lab Fungi Biol, Inst Biosci Botucatu, BR-18618000 Botucatu, SP - Brazil
[4] Unesp Sao Paulo State Univ, Inst Biosci Botucatu, Lab Phytomed Pharmacol & Biotechnol PhytoPharmaTe, BR-18618000 Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 4

Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of B. salicifolius and to identify its main chemical constituents. The essential oil was extracted by steam distillation, chemical composition was determined by gas chromatography/mass spectrometry, and biological activities were performed by a microdilution broth method. The yield of essential oil was 0.86% (w/w), and the main constituents identified were bicyclogermacrene (17.50%), globulol (14.13%), viridiflorol (8.83%), -eudesmol (7.89%) and -eudesmol (6.88%). The essential oil was cytotoxic against the MDA-MB-231 (46.60 gmL(-1)) breast cancer cell line, being more selective for this cell type compared to the normal breast cell line MCF-10A (314.44 gmL(-1)). Flow cytometry and cytotoxicity results showed that this oil does not act by inducing cell death, but rather by impairment of cellular metabolism specifically of the cancer cells. Furthermore, it presented antifungal activity against Paracoccidioides brasiliensis (156.25 gmL(-1)) but was inactive against other fungi and bacteria. Essential oil from B. salicifolius showed promising biological activities and is therefore a source of molecules to be exploited in medicine or by the pharmaceutical industry. (AU)

FAPESP's process: 15/14278-6 - The impact of natural compounds in bacteria of clinical interest
Grantee:Ary Fernandes Júnior
Support type: Regular Research Grants