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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents

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Author(s):
Barbosa-Martins, Luiz Filipe [1] ; de Sousa, Jossaria Pereira [1] ; Freire de Castilho, Aline Rogeria [1] ; Puppin-Rontani, Julia [2] ; Davies, Robert P. W. [3] ; Puppin-Rontani, Regina Maria [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Pediat Dent, 901 Limeira Ave, BR-13414903 Sao Paulo - Brazil
[2] Univ Estadual Campinas, Dept Restorat Dent, Sao Paulo - Brazil
[3] Univ Leeds, Dept Oral Biol, St James Univ Hosp, Leeds, W Yorkshire - England
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS; v. 81, p. 214-221, MAY 2018.
Web of Science Citations: 4
Abstract

Bonding to demineralized dentin of a diseased tooth has shown to be a significant clinical issue. This study evaluated the effect of 0.2% NaF-(NaF), MI Paste (TM)-(CPP-ACP) and the self-assembling peptide `P11-4' (Ace-QQRFEWEFEQQ-NH2) contained in Curodont (TM) Repair, have on microtensile bond strength-(mu TBS) of two different adhesive systems (Adper (TM) Single Bond-(SB) or Clearfil (TM) SE Bond (CSE)) and wettability of demineralized dentin slices after remineralising agents were applied. The highest mu TBS were found for the demineralized dentin-(DD) treated with CPP-ACP; both adhesives systems (p < 0.05) did not significantly difference from P11-4 treatment associated with SB, and also presented higher values than sound dentin-(SD/SB) (p < 0.01). DD treated with P11-4 associated with CSE did not differ from DD/CSE (p > 0.05). The NaF treatment associated with CSE recovered the bond strength values of SD/CSE and associated with CSE demonstrated lower mu TBS than other groups, although significantly higher than DD (p < 0.05). P11-4 and CPP-ACP increased significantly the wettability of demineralized dentin (p < 0.05); etching acid improved wettability for all groups (p < 0.05), whilst NaF did not affect the wettability of demineralized dentin (p > 0.05). Morphological analysis of the dentin surface and dentin-resin interface revealed unique features of the applied remineralizing agent. The results indicated that self-assembling peptide P11-4 associated with SB and CPP-ACP associated with SB or CSE significantly enhanced the bond strength to demineralized dentin (p < 0.05). We conclude that by modifying the dentine surface and restoring conditions found on sound dentin, this can enhance the interfacial bonding. (AU)

FAPESP's process: 15/12660-0 - Effect of remineralizing agents on proteolytic activity and resin/caries-affected dentin bond longevity
Grantee:Regina Maria Puppin Rontani
Support Opportunities: Regular Research Grants
FAPESP's process: 11/16634-3 - Evalution of resistance of union the affected dentin caries for post treatment by diferente substances capacity remineralizing
Grantee:Luiz Filipe Barbosa Martins
Support Opportunities: Scholarships in Brazil - Master