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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory syncytial virus evaluation among asymptomatic and symptomatic subjects in a university hospital in Sao Paulo, Brazil, in the period of 2009-2013

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Moreira, Luciana Peniche [1] ; Aranha Watanabe, Aripuana Sakurada [1] ; Camargo, Clarice Neves [1] ; Melchior, Thais Boim [1] ; Granato, Celso [1] ; Bellei, Nancy [1]
Total Authors: 6
[1] Sao Paulo Fed Univ, Dept Med, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Influenza and Other Respiratory Viruses; v. 12, n. 3, p. 326-330, MAY 2018.
Web of Science Citations: 5

Background: The respiratory syncytial virus (RSV) is recognized as an important cause of respiratory tract infections. Immunocompromised patients, healthcare workers (HCWs) and children contacts are at increased risk of acquiring the infection. However, the impact of asymptomatic infection in transmission has not been well studied. Objectives: this study evaluated the frequency and viral load (VL) of RSV in nasal swab samples of individuals with different risk factors for acquiring infection in a university hospital in Sao Paulo, Brazil. Methods: We included 196 symptomatic children and their 192 asymptomatic caregivers, 70 symptomatic and 95 asymptomatic HCWs, 43 samples from symptomatic HIV-positive outpatients, and 100 samples of asymptomatic HIV patients in the period of 2009-2013. Results: RSV infection was detected in 10.1% (70/696) of samples, 4.4% (17/387) of asymptomatic patients, and 17.1% (53/309) from symptomatic patients. (P < .0001). The VL of symptomatic patients (4.7 log copies/mL) was significantly higher compared to asymptomatic patients (2.3 log copies/mL). RSV detection among asymptomatic caregivers (6.8%; 13/192) was significantly higher compared to other asymptomatic adults, HIV and HCWs (2.0%; 4/195; P = .0252). A close contact with an infected child at home was an important risk to RSV acquisition {[}OR 22.6 (95% CI 4.8-106.7)]. Children who possibly transmitted the virus to their asymptomatic contacts had significantly higher viral load than children who probably did not transmit (P < .0001). Conclusions: According to our results, it is important to know if people circulating inside the hospital have close contact with acute respiratory infected children. (AU)

FAPESP's process: 16/09279-6 - Evaluation of WU and KI polyomavírus frequency in samples of differents populations attended in a tertiary hospital of São Paulo.
Grantee:Nancy Cristina Junqueira Bellei
Support type: Regular Research Grants