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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis

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Author(s):
Mariane Maffei Azuma [1] ; João Eduardo Gomes-Filho [2] ; Carolina de Barros Morais Cardoso [3] ; Camila Barbosa Pipa [4] ; Luis Gustavo Narciso [5] ; Suely Regina Mogami Bomfim [6] ; Rogério de Castilho Jacinto [7] ; Luciano Tavares Angelo Cintra [8]
Total Authors: 8
Affiliation:
[1] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
[2] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
[3] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
[4] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
[5] Universidade Estadual Paulista. Araçatuba School of Veterinary Medicine. Clinic and Surgery and Animal Reproduction - Brasil
[6] Universidade Estadual Paulista. Araçatuba School of Veterinary Medicine. Clinic and Surgery and Animal Reproduction - Brasil
[7] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
[8] Universidade Estadual Paulista. Endodontics, Araçatuba Dental School - Brasil
Total Affiliations: 8
Document type: Journal article
Source: Brazilian Dental Journal; v. 29, n. 2, p. 173-178, 2018-03-00.
Abstract

Abstract The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (w-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with w-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with w-3 PUFAs (AP+O). The administration of w-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with w-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues. (AU)

FAPESP's process: 13/26390-0 - Local and systemic influence of dietary supplementation with omega - 3 in rats with endodontic infection
Grantee:Mariane Maffei Azuma
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/03054-0 - The influence of dietary supplementation with ômega-3 fatty acids in the triglyceride levels and bone resorption in Wistar rats with endodontic infection
Grantee:Carolina de Barros Morais Cardoso
Support Opportunities: Scholarships in Brazil - Scientific Initiation