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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity

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Author(s):
Ludwig, Raissa G. [1, 2] ; Rocha, Andrea L. [1, 2] ; Mori, Marcelo A. [1, 2]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Program Genet & Mol Biol, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Cell Biology International; v. 42, n. 6, SI, p. 701-710, JUN 2018.
Web of Science Citations: 1
Abstract

Obesity may be counteracted by increased energy expenditure. Circulating molecules act in the adipose tissue to influence brown and beige adipocyte function, differentiation, and thermogenic capacity, which in turn affects substrate utilization and impacts energy balance at the organismal level. These molecules have been envisioned as biomarkers and potential candidates for pharmacological interventions to treat obesity. Here we summarize studies that demonstrate the roles of endogenous circulating molecules of a wide variety in regulating the thermogenic potential of brown and beige fat cells. This review describes the state-of-the-art in the field and helps researchers to prioritize their targets in future studies. (AU)

FAPESP's process: 17/07975-8 - Exploring the role of adipose tissue-derived circulating miRNAs in the beneficial effects of exercise training
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants
FAPESP's process: 15/20822-0 - Metabolic characterization of adipocytes in response to serum of rodents subjected to dietary restriction
Grantee:Raissa Guimarães Ludwig
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/01316-7 - Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction
Grantee:Marcelo Alves da Silva Mori
Support type: Regular Research Grants
FAPESP's process: 16/12294-7 - Dicer signalling in adipocytes controlling immune function and activation of beige cells in adipose tissue
Grantee:Andréa Livia Silva Rocha
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics
Grantee:Marcelo Alves da Silva Mori
Support type: Research Projects - Thematic Grants