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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Facilitation of Ca2+-induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment

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Busanello, Estela N. B. [1] ; Figueira, Tiago R. [1] ; Marques, Ana C. [1] ; Navarro, Claudia D. C. [1] ; Oliveira, Helena C. F. [2] ; Vercesi, Anibal E. [1]
Total Authors: 6
[1] Univ Estadual Campinas, Dept Patol Clin, Fac Ciencias Med, Rua Cinco de Junho, BR-13083877 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Biol Estrutural & Func, Inst Biol, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Cell Biology International; v. 42, n. 6, SI, p. 742-746, JUN 2018.
Web of Science Citations: 4

Mitochondrial redox imbalance and high Ca2+ uptake induce the opening of the permeability transition pore (PTP) that leads to disruption of energy-linked mitochondrial functions and triggers cell death in many disease states. In this review, we discuss the major results from our studies investigating the consequences of NAD(P)-transhydrogenase (NNT) deficiency, and of statins treatment for mitochondrial functions and susceptibility to Ca2+-induced PTP. We highlight the aggravation of high fat diet-induced fatty liver disease in the context of NNT deficiency and the role of antioxidants in the prevention of statins toxicity to mitochondria. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 06/59786-0 - Energetic metabolism, intracellular homeostasis of CA2+ and mitochondrial oxidative stress in cell death
Grantee:Aníbal Eugênio Vercesi
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/50400-0 - Mitochondrial energy metabolism, redox state and functionality in cell death and cardiometabolic and neurodegenerative disorders
Grantee:Aníbal Eugênio Vercesi
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/11261-2 - Cellular antioxidant systems response to mitochondrial oxidative stress induced by statins in skelton muscle of hypercholesterolemic mice
Grantee:Estela Natacha Brandt Busanello
Support type: Scholarships in Brazil - Post-Doctorate