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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

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Author(s):
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Maira da Costa Cacemiro [1] ; Juçara Gastaldi Cominal [2] ; Raquel Tognon [3] ; Natalia de Souza Nunes [4] ; Belinda Pinto Simões [5] ; Lorena Lôbo de Figueiredo-Pontes [6] ; Luiz Fernando Bazzo Catto [7] ; Fabíola Traina [8] ; Elizabeth Xisto Souto [9] ; Fabiana Albani Zambuzi [10] ; Fabiani Gai Frantz [11] ; Fabíola Attié de Castro [12]
Total Authors: 12
Affiliation:
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[1] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[2] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[3] Universidade Federal de Juiz de Fora - Brasil
[4] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[5] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[6] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[7] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[8] Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto - Brasil
[9] Hospital Estadual de Transplantes Euryclides de Jesus Zerbini - Brasil
[10] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[11] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
[12] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil
Total Affiliations: 12
Document type: Journal article
Source: Hematology, Transfusion and Cell Therapy; v. 40, n. 2, p. 120-131, 2018-06-00.
Abstract

ABSTRACT Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods: This study examined the plasma cytokine profiles of patients with essential thrombocythemia, primary myelofibrosis, polycythemia vera and of healthy subjects, and analyzed correlations with JAK2 V617F status and clinical-hematological parameters. Results: The proinflammatory cytokine levels were increased in myeloproliferative neoplasm patients, and the presence of the JAK2 V617F mutation was associated with high IP-10 levels in primary myelofibrosis patients. Conclusions: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera patients exhibited different patterns of cytokine production, as revealed by cytokine network correlations. Together, these findings suggest that augmented cytokine levels are associated with the physiopathology of myeloproliferative neoplasms. (AU)

FAPESP's process: 14/04234-9 - Expression of molecules of HIPPO/LATS pathway in chronic neoplasms myeloproliferative
Grantee:Maira da Costa Cacemiro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/21237-4 - DNA METHYLATION PROFILE OF PRE-LEUKEMIC AND LEUKEMIC HEMATOPOIETIC STEM CELLS FROM ACUTE MYELOID LEUKEMIA DETECTED BY A SINGLE CELL DNA METHYLATION ASSAY
Grantee:Fabíola Attié de Castro
Support type: Scholarships abroad - Research
FAPESP's process: 16/03265-3 - Study of CALR del52 and ins5 knock-in mouse models and comparison to the JAK2V617F knock-in mouse model
Grantee:Maira da Costa Cacemiro
Support type: Scholarships abroad - Research Internship - Doctorate