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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners

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Neppelenbroek, Karin Hermana [1] ; Mello Lima, Jozely Francisca [1] ; Hotta, Juliana [1] ; Galitesi, Lucas Lulo [1] ; Pompeia Fraga Almeida, Ana Lucia [1] ; Urban, Vanessa Migliorini [2]
Total Authors: 6
[1] Univ Sao Paulo, Dept Prosthodont, Bauru Sch Dent, Al Octavio Pinheiro Brisola 9-75, BR-17012901 Bauru, SP - Brazil
[2] Univ Estadual Ponta Grossa, Dept Dent, Ponta Grossa - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 2

PurposeTo investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research. Materials and MethodsDumbbell-shaped specimens (n = 7) with a central cross-sectional area of 6 x 3 x 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0.032 g), chlorhexidine diacetate (0.064 g), ketoconazole (0.128 g), miconazole (0.256 g), and itraconazole (0.256 g). After plasticization, specimens were immersed in distilled water at 37 degrees C for 24 hours, 7 or 14 days, and then tested in tension in a universal testing machine at 40 mm/min. Data of tensile strength (MPa) and elongation percentage (%) were submitted to 3-way ANOVA and Tukey's test ( = 0.05). ResultsAt the end of 14 days, the tensile strength for both materials was significantly lower in the groups modified by miconazole and itraconazole compared to the other groups (p < 0.0001), which showed no significant difference between them (p > 0.05). After 7 and 14 days in water, miconazole and itraconazole added into both materials resulted in significantly lower elongation percentages compared to the other antifungal agents and control (p < 0.0001), which were similar to each other (p > 0.05). ConclusionsThe addition of the nystatin, chlorhexidine, and ketoconazole at MICs for C. albicans biofilm resulted in no harmful effects on the tensile strength and elongation percentage of the temporary soft denture liner materials up to 14 days. (AU)

FAPESP's process: 10/07932-8 - Microbiological, structural, mechanical and physical evaluation of resilient materials modified by the addition of antimicrobial agents for denture stomatitis treatment
Grantee:Karin Hermana Neppelenbroek
Support type: Regular Research Grants
FAPESP's process: 11/06479-0 - Effect of incorporation of antimicrobial agents on the ultimate tensile strength of resilient materials for denture base
Grantee:Lucas Lulo Galitesi
Support type: Scholarships in Brazil - Scientific Initiation