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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multimodal early-life stress induces biological changes associated to psychopathologies

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Godoy, Livea Dornela [1] ; Umeoka, Eduardo H. L. [2] ; Ribeiro, Deidiane Elisa [3] ; Santos, Victor Rodrigues [1] ; Antunes-Rodrigues, Jose [1] ; Lourenco Joca, Samia Regiane [4, 5] ; Garcia-Cairasco, Norberto [2, 1]
Total Authors: 7
[1] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, Ave Bandeirantes 3900, BR-14049900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Med, Neurosci & Behav Sci Dept, Sao Paulo - Brazil
[3] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Pharmacol, Sao Paulo - Brazil
[4] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus - Denmark
[5] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Chem & Phys, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Hormones and Behavior; v. 100, p. 69-80, APR 2018.
Web of Science Citations: 3

Evidences suggest the contributive role of early-life stress (ELS) to affective and anxiety disorders. Chronic exposure to the same stressor may generate habituation, while the exposure to different and repeated stressors gradually promotes maladaptive plasticity. Therefore, to further understand the effects of heterotypic stressors during early life period, male Wistar rat pups (P1-P21) were exposed to Multimodal ELS paradigm. Results indicate pups did not habituate to multimodal ELS and neonates respond to both physical and psychogenic stressors. Adult rats that underwent ELS protocol showed significant lower sucrose intake, decreased latency to immobility in the forced swim test and increased latency to light compartment in the light-dark test when compared to control group. Although it has been shown that ELS-induced changes in hippocampus can be used as biomarkers, multimodal ELS did not significantly alter BDNF, Tyrosine Kinase B (TrkB) receptor expression or neurogenesis in the hippocampus. Taken together, these findings indicate that multimodal ELS protocol can be an interesting experimental model for understanding long-term psychiatric disorders associated with stress. Indeed, our data with neurogenesis, BDNF and TrkB, and conflicting data from the literature, suggest that additional studies on synaptic plasticity/intracellular cascades would help to detect the underlying mechanisms. (AU)

FAPESP's process: 15/18773-1 - Translational evaluation of the Hypothalamus-Pituitary-Adrenal axis and the early life stress-induced allostatic load roles on neuroprogression and vulnerability to psychopathologies
Grantee:Eduardo Henrique de Lima Umeoka
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/11339-0 - Early life stress and neurodevelopment: Contributions of glucocorticoid plasticity to maturational timing.
Grantee:Lívea Dornela Godoy
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/17959-1 - Characterization of depressive behaviors and morphological aspects involved in early life stress and audiogenic kindling in war strain
Grantee:Lívea Dornela Godoy
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/01737-7 - Purinergic system involvement in the behavioral consequences of stress and in the antidepressant mechanism of action
Grantee:Deidiane Elisa Ribeiro
Support type: Scholarships in Brazil - Doctorate