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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Qualitative and Quantitative Analysis of Ethanolic Extract and Phenolic Fraction of Jatropha aethiopica (Euphorbiaceae) Leaves and Their Hypoglycemic Potential

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Author(s):
Gamiotea-Turro, Daylin [1, 2] ; Camaforte, Nathalia A. P. [3] ; Valerino-Diaz, Alexander B. [2] ; Ortiz Nunez, Yarelis [1] ; Rinaldo, Daniel [4] ; Dokkedal, Anne L. [3] ; Bosqueiro, Jose R. [3] ; dos Santos, Lourdes Campaner [2]
Total Authors: 8
Affiliation:
[1] Inst Fundamental Res Trop Agr Alejandro de Humbol, Calles 1&2, 17200, Havana 17200 - Cuba
[2] UNESP Sao Paulo State Univ, Chem Inst Araraquara, Rua Prof Francisco Degni, 55 Bairro Quitandinha, BR-14800060 Araraquara, SP - Brazil
[3] UNESP Sao Paulo State Univ, Dept Biol Sci, Fac Sci Bauru, Bairro Nucleo Habitac Presidente Geisel, Av Eng Luiz Edmundo C Coube 14-01, BR-17033360 Bauru, SP - Brazil
[4] UNESP Sao Paulo State Univ, Dept Chem Bauru, Bairro Nucleo Habitac Presidente Geisel, Av Eng Luiz Edmundo C Coube 14-01, BR-17033360 Bauru, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Agricultural and Food Chemistry; v. 66, n. 6, p. 1419-1427, FEB 14 2018.
Web of Science Citations: 2
Abstract

Although Jatropha aethiopica, popularly known in Cuba as ``mata diabetes{''}, is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]beta-D-galactopyranoside (4), a new kaempferol 3-0-alpha-L-rhamnopyranosyl-(1 -> 4)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]-beta-D-galactopyranoside (5), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-{[}alpha-L-rhamnopyranolsyl-(1 -> 6)]beta-n-glucopyranoside (6), rutin (7), kaempferol 3-O-alpha-L-rhamnopyranosyl-(1 -> 6)beta-D-glucopyranoside (8), and quercetin (9). The compounds (1, 4-7) were quantified by high-performance liquid chromatography photodiode array detection (HPLC-PDA) in both the ethanolic extract (62.65 +/- 0.15 mg/g) and phenolic fraction (61.72 +/- 0.23 mg/g). The results obtained show that both ethanolic extract and phenolic fraction contributed toward the improvement of glucose tolerance, which in turn led to a decline in the glucose levels. Remarkably, the ethanolic extract presented a relatively higher promising effect compared to metformin. (AU)

FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
Grantee:Lourdes Campaner dos Santos
Support Opportunities: Regular Research Grants