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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Downregulation of miR-10B{*}is correlated with altered expression of mitotic kinases in osteosarcoma

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Author(s):
Roberto, Gabriela Molinari [1] ; Engel, Edgard Eduard [2] ; Scrideli, Carlos Alberto [3] ; Tone, Luiz Gonzaga [3] ; Brassesco, Maria Sol [4]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Reg Blood Ctr Ribeirao Preto, Ribeirao Preto Sch Med, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Paeditar, Ribeirao Preto Sch Med, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Med & Rehabil Locomotor Syst, Ribeirao Preto Sch Med, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Dept Biol, Fac Philosophy Sci & Letters Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PATHOLOGY RESEARCH AND PRACTICE; v. 214, n. 2, p. 213-216, FEB 2018.
Web of Science Citations: 5
Abstract

Dysregulated mitotic kinases have frequently been associated with cancer. Changes in their expression might result from diverse mechanisms including avoidance of the tight regulation exerted by miRNAs. Herein we show that miR-10b{*} is downregulated in osteosarcoma samples and demonstrate its correlation with PLK1, PLK4, BUB1, and BUBR1, which are strongly intercorrelated. The selection of miRNAs that coordinately target and regulate multiple members of cancer-related pathways are particularly advantageous to tumors. Thus, even though no associations with clinical parameters were found, our data place miR-10b{*} as a tumor suppressor that might contribute to guarantee genomic stability, deserving further functional confirmation. (AU)

FAPESP's process: 15/00524-5 - Influence of miR-10b on proliferation and the invasive potential of osteosarcoma
Grantee:Gabriela Molinari Roberto
Support type: Scholarships in Brazil - Master