Effect of the consumption of a synbiotic diet mousse containing Lactobacillus acidophilus La-5 by individuals with metabolic syndrome: A randomized controlled trial

Author(s)

Xavier-Santos, Douglas ^{[1, 2]} ; Lima, Egidio Dorea ^[3] ; Colado Simao, Andrea Name ^[4] ; Bedani, Raquel ^{[1, 2]} ; Isay Saad, Susana Marta ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Food Res Ctr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, Av Prof Lineu Prestes 580, B16, BR-05508000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Univ Hosp, Av Prof Lineu Prestes 2565, BR-05508000 Sao Paulo, SP - Brazil

^[4] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Av Robert Koch 60, BR-86039440 Londrina, PR - Brazil

• Document type: Journal article
• Source: Journal of Functional Foods; v. 41, p. 55-61, FEB 2018.
• Web of Science Citations: 6

Abstract

This study aimed to evaluate the impact of a synbiotic diet mousse containing Lactobacillus acidophilus La-5 and the prebiotics inulin and fructooligosaccharides on anthropometric and blood pressure measurements, biochemical, inflammatory, haematological, and immunological parameters of volunteers with metabolic syndrome (MetS). In a randomized, double-blind, placebo-controlled trial, forty-five volunteers with MetS were assigned into two groups, each receiving 40 g/day of: synbiotic diet mousse (SDM) (n = 23) and placebo diet mousse (PDM) without pro- and prebiotics (n = 22). All the evaluated parameters were measured at the beginning and after 8 weeks of intervention. The daily intake of SDM and PDM led to significant reductions of total cholesterol and HDL-cholesterol, as well as of immunoglobulins (A and M), and interleukin-1 beta in both groups (p < .05). These results suggest that the presence of the probiotic and prebiotic ingredients in the diet mousse did not show any additional effects on the parameters evaluated in volunteers with MetS. (AU)

• FAPESP's process: 13/07914-8 - FoRC - Food Research Center
• Grantee: Bernadette Dora Gombossy de Melo Franco
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 13/04422-7 - Synbiotic aerated dessert: diet product development and evaluation of the intake effects in individuals with metabolic syndrome.
• Grantee: Douglas Xavier dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate