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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Metabolomic Approach to Predict Breast Cancer Behavior and Chemotherapy Response

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Author(s):
Cardoso, Marcella Regina [1] ; Santos, Juliana Carvalho [1] ; Ribeiro, Marcelo Lima [2] ; Ramiro Talarico, Maria Cecilia [1] ; Viana, Lais Rosa [1] ; Mauricette Derchain, Sophie Francoise [1]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Ctr Atencao Integral Saude Mulher CAISM, Hosp Mulher Prof Dr Jose Aristodemo Pinotti, BR-13083881 Campinas, SP - Brazil
[2] Sao Francisco Univ, Clin Pharmacol & Gastroenterol Unit, BR-13083881 Braganca Paulista, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 19, n. 2 FEB 2018.
Web of Science Citations: 4
Abstract

Although the classification of breast carcinomas into molecular or immunohistochemical subtypes has contributed to a better categorization of women into different therapeutic regimens, breast cancer nevertheless still progresses or recurs in a remarkable number of patients. Identifying women who would benefit from chemotherapy could potentially increase treatment effectiveness, which has important implications for long-term survival. Metabolomic analyses of fluids and tissues from cancer patients improve our knowledge of the reprogramming of metabolic pathways involved in resistance to chemotherapy. This review evaluates how recent metabolomic approaches have contributed to understanding the relationship between breast cancer and the acquisition of resistance. We focus on the advantages and challenges of cancer treatment and the use of new strategies in clinical care, which helps us comprehend drug resistance and predict responses to treatment. (AU)

FAPESP's process: 16/07822-4 - Analysis Of Molecular Biomarkers Associated To Chemoresistance Derived From Breast Cancer Stem Cells
Grantee:Sophie Françoise Mauricette Derchain
Support type: Regular Research Grants