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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress

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Bernardes, Nathalia [1, 2, 3] ; Dias, Danielle da Silva [1] ; Stoyell-Conti, Filipe Fernandes [1] ; Brito-Monzani, Janaina de Oliveira [4, 1] ; Malfitano, Christiane [1, 5] ; Caldini, Elia Garcia [2] ; Ulloa, Luis [6] ; Llesuy, Susana Francisca [7] ; Irigoyen, Maria-Claudia [2] ; De Angelis, Katia [1, 2, 8]
Total Authors: 10
[1] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP - Brazil
[3] Cidade Sao Paulo Univ UNICID, Lab Physiol & Metab, Sao Paulo, SP - Brazil
[4] Univ Fed Maranhao, Sao Luis, MA - Brazil
[5] Fed Univ Lavras UFLA, Dept Hlth Sci, Lavras, MG - Brazil
[6] Rutgers State Univ, Rutgers New Jersey Med Sch, Ctr Immunol & Inflammat, Dept Surg, Newark, NJ - USA
[7] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF - Argentina
[8] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JUN 5 2018.
Web of Science Citations: 2

This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7,15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNF alpha and IL-6 levels in the adipose tissue and IL-1 beta(3 levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome. (AU)

FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
Grantee:Kátia de Angelis Lobo D Avila
Support Opportunities: Regular Research Grants