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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Gene regulatory and signaling networks exhibit distinct topological distributions of motifs

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Author(s):
Ferreira, Gustavo Rodrigues [1] ; Nakaya, Helder Imoto [2] ; Costa, Luciano da Fontoura [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Physical Review E; v. 97, n. 4 APR 27 2018.
Web of Science Citations: 0
Abstract

The biological processes of cellular decision making and differentiation involve aplethora of signaling pathways and gene regulatory circuits. These networks in turn exhibit a multitude of motifs playing crucial parts in regulating network activity. Here we compare the topological placement of motifs in gene regulatory and signaling networks and observe that it suggests different evolutionary strategies in motif distribution for distinct cellular subnetworks. (AU)

FAPESP's process: 14/19323-7 - Long noncoding RNAs as potential biomarkers of arthritis
Grantee:Gustavo Rodrigues Ferreira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/19278-6 - Systems biology of long non-coding RNAs
Grantee:Helder Takashi Imoto Nakaya
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/22308-2 - Intermediate representations in Computational Science for knowledge discovery
Grantee:Roberto Marcondes Cesar Junior
Support type: Research Projects - Thematic Grants