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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin

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Cardoso Siqueira, Vanessa Perosino [1] ; Silveira Evangelista, Marina Izadora [1] ; dos Santos, Alana [1] ; Marcos, Rodrigo Labat [1] ; Ligeiro-de-Oliveira, Ana Paula [1] ; Pavani, Christiane [1] ; Damazo, Amilcar Sabino [2] ; Lino-dos-Santos-Franco, Adriana [1]
Total Authors: 8
[1] Univ Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo - Brazil
[2] Fed Univ Cuiaba, Fac Med Sci, Dept Basic Sci Hlth, Cuiaba - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Biophotonics; v. 10, n. 12, SI, p. 1683-1693, DEC 2017.
Web of Science Citations: 5

Since asthma is a multifactorial disease where treatment sometimes is not effective, new therapies that improve the respiratory discomfort of patients are of great importance. Phototherapy as Light-emitting diode (LED) has emerged as a treatment that presents good results for diseases that are characterized by inflammation. Thus, our objective was to investigate the effects of LED on lung inflammation, by an evaluation of lung cell infiltration, mucus secretion, oedema, and the production of cytokines. Male Balb/c mice were or not sensitized and challenged with ovalbumin (OVA) and treated or not with LED therapy (1 h and 4 h after each OVA challenge). Twenty-four hours after the last OVA challenge, analyzes were performed. Our results showed that LED treatment in asthmatic mice reduced the lung cell infiltration, the mucus production, the oedema, and the tracheal's contractile response. It also increased the IL-10 and the IFN-gamma levels. The effects of LED treatment on lung inflammation may be modulated by IL-10, IFN-gamma, and by mast cells. This study may provide important information about the effects of LED, and in addition, it may open the possibility of a new approach for the treatment of asthma. (AU)

FAPESP's process: 15/08041-3 - Effects of LED therapy on inflammatory parameters in experimental model of asthma
Grantee:Marina Izadora Silveira Evangelista
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/00830-9 - Effects of exposure to ambient/occupational pollution on idiopathic pulmonary fibrosis
Grantee:Adriana Lino dos Santos Franco
Support type: Regular Research Grants