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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serological Survey of Hantavirus in Inhabitants from Tropical and Subtropical Areas of Brazil

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Morais, Felipe Alves [1, 2] ; Pereira, Alexandre [3] ; Pietro Pereira, Aparecida Santo [4, 3] ; Moreli, Marcos Lazaro [5] ; Aranha Camargo, Luis Marcelo [6, 7] ; Nardi, Marcello Schiavo [8, 9] ; Tofoli, Cristina Farah [8] ; Araujo, Jansen [1] ; Dutra, Lilia Mara [1] ; Ometto, Tatiana Lopes [1] ; Hurtado, Renata [1] ; de Jesus Maues, Fabio Carmona [1] ; Hinke, Tiene Zingano [6] ; Mahmud, Sati Jaber [6] ; Lima, Monica Correia [10] ; Moraes Figueiredo, Luiz Tadeu [11] ; Durigon, Edison Luiz [1]
Total Authors: 17
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[1] Univ Sao Paulo, Lab Virol Clin & Mol, Dept Microbiol, Inst Ciencias Biomed, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Lab Sinalizacao Mol, Dept Bioquim, Inst Quim, BR-05508000 Sao Paulo, SP - Brazil
[3] Inst Butantan, Lab Genet, BR-05503900 Sao Paulo, SP - Brazil
[4] Inst Butantan, Lab Virol, BR-05503900 Sao Paulo, SP - Brazil
[5] Univ Fed Goias, Lab Virol, BR-75801615 Jatai, Go - Brazil
[6] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05389970 Sao Paulo, SP - Brazil
[7] Sao Lucas Med Sch, Rua Alexandre Guimaraes 1928, BR-76000000 Porto Velho, RO - Brazil
[8] IPE, BR-12960000 Nazare Paulista, SP - Brazil
[9] Div Tecn Med Vet & Manejo Fauna Silvestre DEPAVE, BR-04030000 Prefeitura De Sao Paulo, SP - Brazil
[10] Dept Municipal Saude, BR-11950000 Prefeitura De Cajati, SP - Brazil
[11] Univ Sao Paulo, Ctr Pesquisa Virol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 11
Document type: Journal article
Web of Science Citations: 0

Brazil has reported more than 1,600 cases of hantavirus cardiopulmonary syndrome (HPS) since 1993, with a 39% rate of reported fatalities. Using a recombinant nucleocapsid protein of Araraquara virus, we performed ELISA to detect IgG antibodies against hantavirus in human sera. The aim of this study was to analyze hantavirus antibody levels in inhabitants from a tropical area (Amazon region) in Rondonia state and a subtropical (Atlantic Rain Forest) region in Sao Paulo state, Brazil. A total of 1,310 serum samples were obtained between 2003 and 2008 and tested by IgG-ELISA, and 82 samples (6.2%), of which 62 were from the tropical area (5.8%) and 20 from the subtropical area (8.3%), tested positive. Higher levels of hantavirus antibody were observed in inhabitants of the populous subtropical areas compared with those from the tropical areas in Brazil. (AU)

FAPESP's process: 05/01603-4 - Serological detection of hantavirus in wild and human animal samples in the state of São Paulo by Western Blotting and ELISA assay using recombinant protein developed in Brazil
Grantee:Felipe Alves Morais
Support type: Scholarships in Brazil - Doctorate (Direct)