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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Graves' ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts

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Cury, Sarah Santiloni [1] ; Oliveira, Miriane [1] ; Sibio, Maria Teresa [1] ; Clara, Sueli [1] ; Melo Luvizotto, Renata De Azevedo [1] ; Conde, Sandro [2] ; Jorge, Edson Nacib [3] ; Nunes, Vania dos Santos [1] ; Nogueira, Celia Regina [1] ; Ferreira da Silva Mazeto, Glaucia Maria [1]
Total Authors: 10
[1] Univ Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Med Interna, Div Endocrinol, Botucatu, SP - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Estado Sao Paulo I, Sao Roque, SP - Brazil
[3] Univ Estadual Sao Paulo Unesp, Fac Med Botucatu, Dept Oftalmol Otorrinolaringol & Cirurgia Cabeca, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 62, n. 3, p. 366-369, MAY-JUN 2018.
Web of Science Citations: 0

Objective: Graves' ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RAR alpha) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. Materials and methods: Orbital fibroblasts collected during orbital decompression of a female patient with moderately severe/severe GO were cultivated and treated with 10 nM and 100 nM dexamethasone (Dex). RAR alpha gene expression in the treated and untreated cells was then compared. Result: Fibroblast RAR alpha expression was not affected by 100 nM Dex On the other hand, RAR alpha expression was 24% lower in cells treated with 10 nM Dex (p < 0.05). Conclusion: Orbital fibroblasts from a GO patient expressed the RAR alpha gene, which was unaffected by higher, but decreased with lower doses of glucocorticoid. (AU)

FAPESP's process: 11/18464-8 - Gene expression of different hormone receptors in orbital fibroblasts, undergo adipocytic differentiation in patients with Graves' ophthalmopathy
Grantee:Sarah Santiloni Cury
Support type: Scholarships in Brazil - Scientific Initiation