Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies

Author(s)

Mueller-Coan, Barbara Grasiele ^{[1, 2]} ; Ramos Caetano, Brunno Felipe ^{[1, 2]} ; Pagano, Joseph Stephen ^[3] ; de Oliveira, Deilson Elgui ^{[1, 2]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Med Sch Botucatu, Av Prof Mario Rubens Guimaraes Montenegro S-N, BR-18618687 Botucatu, SP - Brazil

^[2] UNESP, Inst Biotechnol IBTEC, AlamedadasTecomarias S-N, BR-18607440 Botucatu, SP - Brazil

^[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 - USA

• Document type: Review article
• Source: TRENDS IN CANCER; v. 4, n. 7, p. 485-498, JUL 2018.
• Web of Science Citations: 3

Abstract

Cancer progression is the most relevant phase of carcinogenesis due to the development of malignant tumors in the host. Some viruses participate in malignant cell transformation, with recent compelling evidence suggesting that oncoviruses also have a role in cancer progression. The human hepatitis B (HBV) and C (HCV) viruses, human papillomaviruses (HPV), Epstein Barr virus (EBV), and Kaposi sarcoma herpesvirus (KSHV) are the most important human oncoviruses currently known. Here, we discuss how oncoviruses can modulate cancer progression, such as tumor growth, invasion, and cancer metastasis. (AU)

• FAPESP's process: 14/17326-9 - Effects of LMP1 protein of Epstein-Barr virus isolates B95-8 and M81 in the invasive potential of human carcinoma cells, and regulation of endogenous miRNAs and proteins implicated in cancer progression
• Grantee: Deilson Elgui de Oliveira
• Support Opportunities: Regular Research Grants