| Full text | |
| Author(s): |
Dombrowski, Jamille Gregorio
[1]
;
de Souza, Rodrigo Medeiros
[2]
;
Mendes Silva, Natercia Regina
[1]
;
Barateiro, Andre
[1]
;
Epiphanio, Sabrina
[3]
;
Goncalves, Ligia Antunes
[1]
;
Farias Marinho, Claudio Romero
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[2] Univ Fed Acre, Multidisciplinary Ctr, Acre - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PLoS One; v. 13, n. 6 JUN 21 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Background Malaria in pregnancy (MiP) is one of the major causes of mortality and morbidity in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems on pregnancy and malaria could prove to be a useful method of improved decision making for better maternal-child health. Methods A population-based observational study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil). Social and clinical data of the mother and newborn was extracted from the Information System of Live Births. Malaria episodes information was obtained from the Brazilian Epidemiological Surveillance Information System Malaria. A deterministic record linkage was performed to assess malaria impact on pregnancy. Results The studied population presented a malaria incidence of 8.9% (1283 pregnant women infected), of which 63.9% infected by Plasmodium (P.) vivax. Reduction of newborn birth weight at term (small for gestational age (SGA) and LBW) has been found associated with P. vivax infection during pregnancy (SGA-OR 1.24, 95% CI 1.02-1.52, p = 0.035; term LBW OR 1.39, 95% CI 1.03-1.88, p = 0.033). Additionally, P. falciparum infection during pregnancy has been found to be associated with preterm births (OR 1.54, 95% CI 1.09-2.18, p = 0.016), which is related with late preterm births (OR 1.59, 95% CI 1.11-2.27, p = 0.011). Conclusions Despite the decrease of malaria cases during the evaluation period and regardless of Plasmodium species, we present evidence of the deleterious effects of MiP in a low transmission area in the Amazonian region. (AU) | |
| FAPESP's process: | 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Visiting Researcher Grant - International |
| FAPESP's process: | 17/03939-7 - Impact of autophagy and inflammasome on the pathogenesis of Placental Malaria |
| Grantee: | André Filipe Rivais Martins Barateiro |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/04755-3 - Association of gestational malaria with intrauterine growth restriction and low birth weight in the far-western Brazilian Amazon |
| Grantee: | Jamille Gregório Dombrowski |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 14/20451-0 - The role of endothelial cells in the immunopathogenesis of murine malaria-associated ALI/ARDS: effects and mechanisms |
| Grantee: | Sabrina Epiphanio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/09964-5 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/53889-0 - Study of the immunopathological mechanisms involved in pregnancy-associated malaria |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Research Grants - Young Investigators Grants |