Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural infection of Neotropical bats with hantavirus in Brazil

Full text
Author(s):
Show less -
Sabino-Santos, Jr., Gilberto [1] ; Motta Maia, Felipe Goncalves [2, 1] ; Martins, Ronaldo Braganca [1] ; Gagliardi, Talita Bianca [1] ; de Souza, William Marciel [1] ; Muylaert, Renata Lara [3] ; de Souza Luna, Luciano Kleber [1] ; Melo, Danilo Machado [1] ; Cardoso, Ricardo de Souza [1] ; Barbosa, Natalia da Silva [4] ; Pontelli, Marjorie Cornejo [1] ; Mamani-Zapana, Priscila Rosse [1] ; Vieira, Thallyta Maria [5] ; Melo, Norma Maria [6] ; Jonsson, Colleen B. [7] ; Goodin, Douglas [8] ; Salazar-Bravo, Jorge [9] ; Pinto dasilva, Luis Lamberti [4] ; Arruda, Eurico [1] ; Moraes Figueiredo, Luiz Tadeu [1]
Total Authors: 20
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Virol Res, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo - Brazil
[3] Sao Paulo State Univ, Dept Ecol, Rio Claro - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Cell & Mol Biol, Ribeirao Preto - Brazil
[5] Univ Estadual Montes Claros, Dept Biol Sci, Montes Claros, MG - Brazil
[6] Univ Fed Minas Gerais, Inst Biol Sci, Dept Parasitol, Belo Horizonte, MG - Brazil
[7] Natl Inst Math & Biol Synth, Dept Microbiol, Knoxville, TN - USA
[8] Kansas State Univ, Dept Geog, Manhattan, KS 66506 - USA
[9] Texas Tech Univ, Dept Biol Sci, Lubbock, TX 79409 - USA
Total Affiliations: 9
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JUN 13 2018.
Web of Science Citations: 1
Abstract

Bats (Order: Chiroptera) harbor a high diversity of emerging pathogens presumably because their ability to fly and social behavior favor the maintenance, evolution, and dissemination of these pathogens. Until 2012, there was only one report of the presence of Hantavirus in bats. Historically, it was thought that these viruses were harbored primarily by rodent and insectivore small mammals. Recently, new species of hantaviruses have been identified in bats from Africa and Asia continents expanding the potential reservoirs and range of these viruses. To assess the potential of Neotropical bats as hosts for hantaviruses and its transmission dynamics in nature, we tested 53 bats for active hantaviral infection from specimens collected in Southeastern Brazil. Part of the hantaviral S segment was amplified from the frugivorous Carollia perspicillata and the common vampire bat Desmodus rotundus. DNA sequencing showed high similarity with the genome of Araraquara orthohantavirus (ARQV), which belongs to one of the more lethal hantavirus clades (Andes orthohantavirus). ARQV-like infection was detected in the blood, urine, and organs of D. rotundus. Therefore, we describe a systemic infection in Neotropical bats by a human pathogenic Hantavirus. We also propose here a schematic transmission dynamics of hantavirus in the study region. Our results give insights to new, under-appreciated questions that need to be addressed in future studies to clarify hantavirus transmission in nature and avoid hantavirus outbreaks. (AU)

FAPESP's process: 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/06142-7 - Characterization of host cell factors involved in the budding and egress of Oropouche virus
Grantee:Natalia da Silva Barbosa
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/03700-0 - Two issues regarding the human rhinoviruses: the inhibitory effect of 2A protease on the induction of interferon and a search for a natural animal host
Grantee:Talita Bianca Gagliardi
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/06380-0 - Rhinovirus replication in explants of human tonsillar lymphoepithelial tissue infected ex vivo
Grantee:Ronaldo Bragança Martins Júnior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/19897-5 - Emerging picornaviruses and coronaviruses: association with respiratory pathogenesis in humans and detection in wild rodents
Grantee:Luciano Kleber de Souza Luna
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/04096-0 - BAT diversity in Cerrado landscapes: is there a fragmentation threshold?
Grantee:Renata de Lara Muylaert
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/05354-0 - Functional analysis of the m segment non-structural protein (NSm) of Orthobunyavirus Oropouche
Grantee:Marjorie Cornejo Pontelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/02568-2 - Research on hantavirus and other viruses in wild small mammals and their ectoparasites
Grantee:Gilberto Sabino dos Santos Junior
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/06810-9 - Detection and ecology of hantavirus among wild small mammals and their ectoparasites
Grantee:Gilberto Sabino dos Santos Junior
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/02438-6 - Studies with Bunyaviridae that produce human disease
Grantee:Luiz Tadeu Moraes Figueiredo
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/22663-6 - Study of the occurence of arboviroses in wild animals and mosquitoes in Brazilian biomes and agroecosystems
Grantee:Felipe Gonçalves Motta Maia
Support type: Scholarships in Brazil - Doctorate