SOD2 immunoexpression predicts lymph node metastasis in penile cancer

Author(s):Show less -

Termini, Lara ^[1] ; Fregnani, Jose H. ^[2] ; Boccardo, Enrique ^[3] ; da Costa, Walter H. ^[4] ; Longatto-Filho, Adhemar ^{[5, 6, 7]} ; Andreoli, Maria A. ^[1] ; Costa, Maria C. ^[1] ; Lopes, Ademar ^[4] ; da Cunha, Isabela W. ^[8] ; Soares, Fernando A. ^[8] ; Villa, Luisa L. ^{[1, 9, 10]} ; Guimaraes, Gustavo C. ^[4]

Affiliation

^[1] Santa Casa Sao Paulo, INCT HPV Santa Casa Res Inst, Sch Med, Rua Marques Itu 381, BR-01223001 Sao Paulo - Brazil

^[2] Barretos Canc Hosp, Teaching & Res Inst, BR-14784006 Barretos - Brazil

^[3] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, BR-05508900 Sao Paulo - Brazil

^[4] AC Camargo Canc Ctr, Pelv Surg Dept, BR-01509010 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Med Invest LIM 14, BR-01246903 Sao Paulo - Brazil

^[6] Univ Minho, ICVS PT Govt Associate Lab 3Bs, Life & Hlth Sci Res Inst, Sch Hlth Sci, Braga, Guimaraes - Portugal

^[7] Barretos Canc Hosp, Mol Oncol Res Ctr, BR-14784400 Barretos, Barretos - Brazil

^[8] AC Camargo Canc Ctr, Dept Anat Pathol, BR-01509900 Sao Paulo - Brazil

^[9] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, BR-01246000 Sao Paulo - Brazil

^[10] ICESP, Canc Inst State Sao Paulo, BR-01246000 Sao Paulo - Brazil

• Document type: Journal article
• Source: BMC CLINICAL PATHOLOGY; v. 15, MAR 3 2015.
• Web of Science Citations: 6

Abstract

Background: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, colorectal, breast cancer and cervical cancer malignant tumors has been observed. Its relationship with inguinal lymph node metastasis in penile cancer is unknown. Methods: SOD2 protein expression levels were determined by immunohistochemistry in 125 usual type squamous cell carcinomas of the penis from a Brazilian cancer center. The casuistic has been characterized by means of descriptive statistics. An exploratory logistic regression has been proposed to evaluate the independent predictive factors of lymph node metastasis. Results: SOD2 expression in more than 50% of cells was observed in 44.8% of primary penile carcinomas of the usual type. This expression pattern was associated with lymph node metastasis both in the uni and multivariate analysis. Conclusions: Our results indicate that SOD2 expression predicts regional lymph node metastasis. The potential clinical implication of this observation warrants further studies. (AU)

• FAPESP's process: 08/57889-1 - Institute of Science and Technology to study Diseases Associated with Papillomavirus
• Grantee: Luisa Lina Villa
• Support Opportunities: Research Projects - Thematic Grants