aPDT for periodontitis treatment in ovariectomized... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

aPDT for periodontitis treatment in ovariectomized rats under systemic nicotine

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Author(s):
Garcia, Valdir Gouveia [1] ; Gualberto Junior, Erivan Clementino [1] ; Ervolino, Edilson [1, 2] ; Hitomi Nagata, Maria Jose [1] ; de Almeida, Juliano Milanezi [1] ; Theodoro, Leticia Helena [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Grp Res & Study Laser Dent, Dept Surg & Integrated Clin, Div Periodont, Sch Dent, 1193 Jose Bonifacio, BR-16015050 Aracatuba, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Basic Sci, Sch Dent, 1193 Jose Bonifacio, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 22, p. 70-78, JUN 2018.
Web of Science Citations: 6
Abstract

Background-This study evaluated the antimicrobial photodynamic therapy (aPDT) as an adjunctive therapy to scaling and root planning (SRP) for the treatment of experimental periodontitis (EP) in ovariectomized rats under systemic nicotine. Methods: Female ovariectomized rats (n = 180) were divided into two groups: vehicle administration (Veh) and nicotine administration (Nic). Mini-pumps containing either vehicle or nicotine were inserted in the rats 30 days before the induction of EP, which was induced by placing a ligature around the left mandibular first molar. The rats were randomly divided into three treatment subgroups: SRP, SRP plus low-level laser therapy (LLLT), and SRP plus aPDT. aPDT consisted of the application of a phenothiazine photosensitizer followed by LLLT. Ten animals from each group were euthanized at days 7, 15, and 30 after periodontal treatment. The furcation region was evaluated using histological, histometric analyses and immunolabelling for PCNA, TRAP, RANKL, and OPG. Results: Nicotine administration resulted in greater bone loss (BL). aPDT resulted in lower BL compared to SRP. aPDT showed higher quantities of PCNA-positive cells compared to SRP, regardless of the nicotine status. aPDT resulted in less recruitment of osteoclasts and lower RANKL immunolabelling compared to LLLT and SRP. Conclusion: aPDT was effective in animals treated with nicotine. (AU)

FAPESP's process: 10/15094-2 - Effects of laser and photodynamic therapy as adjuvant to mechanical periodontal treatment in ovariectomized rats under systemic influence of nicotine: A histomorphometric and immunhistochemical study.
Grantee:Erivan Clementino Gualberto Júnior
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/00936-0 - Effects of laser and photodynamic therapy as adjuvant to mechanical periodontal treatment in ovariectomized rats under systemic influence of nicotine: A histomorphometric and immunhistochemical study
Grantee:Maria José Hitomi Nagata
Support Opportunities: Regular Research Grants