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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors

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Author(s):
Yamashita, Alex S. [1] ; Belchior, Thiago [1] ; Lira, Fabio S. [2] ; Bishop, Nicolette C. [3] ; Wessner, Barbara [4] ; Rosa, Jose C. [5] ; Festuccia, William T. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP - Brazil
[3] Loughborough Univ Technol, Sch Sports Exercise & Hlth Sci, Loughborough, Leics - England
[4] Ctr Sport Sci & Univ Sports, Vienna - Austria
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Cell Biol & Dev, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Review article
Source: Mediators of Inflammation; 2018.
Web of Science Citations: 7
Abstract

Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic beta-cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic beta-cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation. (AU)

FAPESP's process: 13/15825-5 - Searching new therapies for insulin resistance: development of a platform for drug screening and preclinical in vivo assay
Grantee:Alex Shimura Yamashita
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/22983-1 - Discovery of new transcription factors involved in the development of steatosis, steatohepatitis, and liver cancer
Grantee:Thiago Belchior de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/19530-5 - Involvement of the nutrient sensor mTOR in the development of obesity associated chronic metabolic diseases
Grantee:William Tadeu Lara Festuccia
Support type: Research Projects - Thematic Grants