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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heparan Sulfate Proteoglycans in Human Colorectal Cancer

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Author(s):
Vicente, Carolina Meloni [1] ; da Silva, Daiana Aparecida [1] ; Sartorio, Priscila Veronica [2] ; Silva, Tiago Donizetti [3] ; Saad, Sarhan Sydney [4] ; Nader, Helena Bonciani [1] ; Forones, Nora Manoukian [3] ; Toma, Leny [1]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Biol Mol, Rua Tres de Maio, 100 4 Andar, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Farmacol Celular, Rua Tres de Maio, 100 4 Andar, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Gastroenterol, Rua Loefgreen 1726, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Gastroenterol Cirurg, Rua Napoleao Barros, 715 2 Andar, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: ANALYTICAL CELLULAR PATHOLOGY; 2018.
Web of Science Citations: 3
Abstract

Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis. Therefore, it is crucial to investigate molecules involved in colorectal cancer tumorigenesis, with possible use as tumor markers. Heparan sulfate proteoglycans are complex molecules present in the cell membrane and extracellular matrix, which play vital roles in cell adhesion, migration, proliferation, and signaling pathways. In colorectal cancer, the cell surface proteoglycan syndecan-2 is upregulated and increases cell migration. Moreover, expression of syndecan-1 and syndecan-4, generally antitumor molecules, is reduced. Levels of glypicans and perlecan are also altered in colorectal cancer; however, their role in tumor progression is not fully understood. In addition, studies have reported increased heparan sulfate remodeling enzymes, as the endosulfatases. Therefore, heparan sulfate proteoglycans are candidate molecules to clarify colorectal cancer tumorigenesis, as well as important targets to therapy and diagnosis. (AU)

FAPESP's process: 16/18066-6 - The role of proteoglycan´s microdomains-6-O-sulfated in tumor biology and tissues.
Grantee:Leny Toma
Support type: Regular Research Grants
FAPESP's process: 15/03964-6 - Glycosaminoglycans and proteoglycans: interplay between structure and function
Grantee:Helena Bonciani Nader
Support type: Research Projects - Thematic Grants