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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Atlas of Schistosoma mansoni long non-coding RNAs and their expression correlation to protein-coding genes

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Author(s):
Vasconcelos, Elton J. R. [1, 2, 3] ; Mesel, Vinicius C. [2] ; daSilva, Lucas F. [1, 2] ; Pires, David S. [2] ; Lavezzo, Guilherme M. [1, 2] ; Pereira, Adriana S. A. [1, 2] ; Amaral, Murilo S. [2] ; Verjovski-Almeida, Sergio [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508900 Sao Paulo, SP - Brazil
[2] Inst Butantan, Lab Expressao Genica Eucariotos, BR-05503900 Sao Paulo, SP - Brazil
[3] Western Univ Hlth Sci, Coll Vet Med, Pomona, CA 91766 - USA
Total Affiliations: 3
Document type: Journal article
Source: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION; JUL 9 2018.
Web of Science Citations: 0
Abstract

Long non-coding RNAs (lncRNAs) have been widely discovered in several organisms with the help of high-throughput RNA sequencing. LncRNAs are over 200 nt-long transcripts that do not have protein-coding (PC) potential, having been reported in model organisms to act mainly on the overall control of PC gene expression. Little is known about the functionality of lncRNAs in evolutionarily ancient non-model metazoan organisms, like Schistosoma mansoni, the parasite that causes schistosomiasis, one of the most prevalent infectious-parasitic diseases worldwide. In a recent transcriptomics effort, we identified thousands of S. mansoni lncRNAs predicted to be functional along the course of parasite development. Here, we present an online catalog of each of the S. mansoni lncRNAs whose expression is correlated to PC genes along the parasite lifecycle, which can be conveniently browsed and downloaded through a new web resource http://verjolab.usp.br. We also provide access now to navigation on the co-expression networks disclosed in our previous publication, where we correlated mRNAs and lncRNAs transcriptional patterns across five life-cycle stages/forms, pinpointing biological processes where lncRNAs might act upon. (AU)

FAPESP's process: 16/10046-6 - Effect of GSK343, an inhibitor of the histone methyltransferase EZH2, on the parasite Schistosoma mansoni
Grantee:Adriana Silva Andrade Pereira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/24560-8 - Identification and characterization of regulatory Long Non-coding RNAs on the Schistosoma mansoni genome through NGS strategies and systems approach
Grantee:Elton José Rosas de Vasconcelos
Support type: Scholarships in Brazil - Post-Doctorate